Featured Research

from universities, journals, and other organizations

Finnish researchers discover regulator of human cell activity

Date:
November 20, 2011
Source:
Technical Research Centre of Finland (VTT)
Summary:
Researchers in Finland have discovered that the SHARPIN protein regulates human cell activity.

Research teams headed by Prof. Johanna Ivaska (University of Turku and VTT Technical Research Centre of Finland) and Prof. Marko Salmi (University of Turku and the National Institute for Health and Welfare) have discovered that the SHARPIN protein regulates human cell activity.

Related Articles


Published in Nature Cell Biology, the study concludes that SHARPIN regulates the movement and activity of inflammatory cells and of lung and prostate cancer cells. It is likely that the discovery will also have significant implications for other conditions such as Crohn's disease, psoriasis, rheumatism and even MS.

The hypothesis that there must be a protein that inhibits cell activity was posited as far back as in the early 1990s. Researchers have now shown that SHARPIN is the hypothesised protein.

Juha Rantala and Jeroen Pouwels, members of Prof. Ivaska's research team, discovered the role of SHARPIN using a cell chip screening method developed at VTT. Using this method, the impacts of all genes in an entire genome can be examined in a single test.


Story Source:

The above story is based on materials provided by Technical Research Centre of Finland (VTT). Note: Materials may be edited for content and length.


Journal Reference:

  1. Juha K. Rantala, Jeroen Pouwels, Teijo Pellinen, Stefan Veltel, Petra Laasola, Elina Mattila, Christopher S. Potter, Ted Duffy, John P. Sundberg, Olli Kallioniemi, Janet A. Askari, Martin J. Humphries, Maddy Parsons, Marko Salmi, Johanna Ivaska. SHARPIN is an endogenous inhibitor of β1-integrin activation. Nature Cell Biology, 2011; 13 (11): 1315 DOI: 10.1038/ncb2340

Cite This Page:

Technical Research Centre of Finland (VTT). "Finnish researchers discover regulator of human cell activity." ScienceDaily. ScienceDaily, 20 November 2011. <www.sciencedaily.com/releases/2011/11/111116081759.htm>.
Technical Research Centre of Finland (VTT). (2011, November 20). Finnish researchers discover regulator of human cell activity. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2011/11/111116081759.htm
Technical Research Centre of Finland (VTT). "Finnish researchers discover regulator of human cell activity." ScienceDaily. www.sciencedaily.com/releases/2011/11/111116081759.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins