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Engineered botulism toxins could have broader role in medicine

Date:
November 30, 2011
Source:
American Chemical Society
Summary:
The most poisonous substance on Earth -- already used medically in small doses to treat certain nerve disorders and facial wrinkles -- could be re-engineered for an expanded role in helping millions of people with rheumatoid arthritis, asthma, psoriasis and other diseases, scientists are reporting.

The most poisonous substance on Earth — already used medically in small doses to treat certain nerve disorders and facial wrinkles — could be re-engineered for an expanded role in helping millions of people with rheumatoid arthritis, asthma, psoriasis and other diseases, scientists are reporting.
Credit: U.S. Centers for Disease Control and Prevention

The most poisonous substance on Earth -- already used medically in small doses to treat certain nerve disorders and facial wrinkles -- could be re-engineered for an expanded role in helping millions of people with rheumatoid arthritis, asthma, psoriasis and other diseases, scientists are reporting. Their study appears in ACS' journal Biochemistry.

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Edwin Chapman and colleagues explain that toxins, or poisons, produced by Clostridium botulinum bacteria, cause of a rare but severe form of food poisoning, are the most powerful toxins known to science. Doctors can inject small doses, however, to block the release of the neurotransmitters, or chemical messengers, that transmit signals from one nerve cell to another. The toxins break down a protein in nerve cells that mediates the release of neurotransmitters, disrupting nerve signals that cause pain, muscle spasms and other symptoms in certain diseases. That protein exists not just in nerve cells, but in other cells in the human body. However, these non-nerve cells lack the receptors needed for the botulinum toxins to enter and work. Chapman's group sought to expand the potential use of the botulinum toxins by hooking it to a molecule that can attach to receptors on other cells.

Their laboratory experiments showed that these engineered botulinum toxins do work in non-nerve cells, blocking the release of a protein from immune cells linked to inflammation, which is the underlying driving force behind a range of diseases. Such botulinum toxin therapy holds potential in a range of chronic inflammatory diseases and perhaps other conditions, which could expand the role of these materials in medicine.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Felix L. Yeh, Yiming Zhu, William H. Tepp, Eric A. Johnson, Paul J. Bertics, Edwin R. Chapman. Retargeted Clostridial Neurotoxins as Novel Agents for Treating Chronic Diseases. Biochemistry, 2011; 50 (48): 10419 DOI: 10.1021/bi201490t

Cite This Page:

American Chemical Society. "Engineered botulism toxins could have broader role in medicine." ScienceDaily. ScienceDaily, 30 November 2011. <www.sciencedaily.com/releases/2011/11/111130100451.htm>.
American Chemical Society. (2011, November 30). Engineered botulism toxins could have broader role in medicine. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2011/11/111130100451.htm
American Chemical Society. "Engineered botulism toxins could have broader role in medicine." ScienceDaily. www.sciencedaily.com/releases/2011/11/111130100451.htm (accessed March 29, 2015).

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