Featured Research

from universities, journals, and other organizations

Promising results in mice on needle-free candidate universal vaccine against various flu viruses

Date:
December 22, 2011
Source:
International Vaccine Institute
Summary:
Scientists have discovered that an antigen common to most influenza viruses, and commonly referred to as matrix protein 2, when administered under the tongue could protect mice against experimental infection caused by various influenza viruses, including the highly pathogenic avian H5 virus and the pandemic H1 virus.

Scientists from the International Vaccine Institute (IVI) have discovered that an antigen common to most influenza viruses, and commonly referred to as matrix protein 2 (M2), when administered under the tongue could protect mice against experimental infection caused by various influenza viruses, including the highly pathogenic avian H5 virus and the pandemic H1 ("swine flu") virus.

Related Articles


Importantly, this experimental sublingual vaccine was found to induce immunity in the lungs whereas the same vaccine administered by injection failed to do so and conferred only limited protection against experimental infection. The study, spearheaded by IVI scientist Dr. Man-ki Song and Dr. Haryoung Poo from the Korea Research Institute of Bioscience and Biotechnology (KRIBB), was reported in the November 30th issue of the journal PLoS ONE.

Current seasonal influenza vaccines are designed to induce immunity against hemagglutinin (HA), a major component of influenza virus. Because HA undergoes frequent mutations, these vaccines have to be reformulated and manufactured every year to incorporate newly emerging influenza virus strains selected by the World Health Organization.

Due to the recent emergence of highly pathogenic influenza virus strains and the threat of a human flu pandemic, health authorities and vaccine producers are under increasing pressure to manufacture and deliver a sufficient number of vaccine doses in a short time, amid a limited global production capacity.

The influenza virus M2 has already been considered as a rational target antigen for development of a universal flu vaccine because this protein is highly conserved among the different types of influenza viruses. However, attempts to develop M2-based vaccines administered by injection have been unsuccessful.

"Sublingual vaccination with M2 induced immune responses in the lungs of mice whereas the same vaccine administered by injection failed to do so. This is probably why earlier attempts involving injection of M2-based vaccines failed to protect against influenza infection and disease," said Dr. Man-ki Song, IVI scientist and lead author of the study. "This vaccination approach offers an additional strategy to prevent influenza infection and may be used to control potential influenza pandemics."

Plans to test this vaccination approach in humans are being considered. "This study suggests that aside from being a more convenient way to immunize people, sublingual vaccination induces special immune responses in the respiratory tract which are important in protection but more difficult to generate with traditional injectable vaccines. Clearly, if these promising findings obtained in laboratory animals can be reproduced in humans, they will represent a major milestone in the IVI R&D agenda." said Dr. Cecil Czerkinsky, IVI Deputy Director-General for Laboratory Sciences.

The study was supported by the National Agenda Project of the Korea Research Council of Fundamental Science and Technology. Dr Christian Loucq, IVI Director-General, said, "Since pandemic influenza remains a global threat and would most likely start in the Asia-Pacific region, this study underscores IVI and the Republic of Korea's commitments to join global efforts to build preparedness for and response to pandemic influenza."


Story Source:

The above story is based on materials provided by International Vaccine Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Byoung-Shik Shim, Young Ki Choi, Cheol-Heui Yun, Eu-Gene Lee, Yoon Seong Jeon, Sung-Moo Park, In Su Cheon, Dong-Hyun Joo, Chung Hwan Cho, Min-Suk Song, Sang-Uk Seo, Young-Ho Byun, Hae-Jung Park, Haryoung Poo, Baik Lin Seong, Jae Ouk Kim, Huan Huu Nguyen, Konrad Stadler, Dong Wook Kim, Kee-Jong Hong, Cecil Czerkinsky, Man Ki Song. Sublingual Immunization with M2-Based Vaccine Induces Broad Protective Immunity against Influenza. PLoS ONE, 2011; 6 (11): e27953 DOI: 10.1371/journal.pone.0027953

Cite This Page:

International Vaccine Institute. "Promising results in mice on needle-free candidate universal vaccine against various flu viruses." ScienceDaily. ScienceDaily, 22 December 2011. <www.sciencedaily.com/releases/2011/12/111208101756.htm>.
International Vaccine Institute. (2011, December 22). Promising results in mice on needle-free candidate universal vaccine against various flu viruses. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2011/12/111208101756.htm
International Vaccine Institute. "Promising results in mice on needle-free candidate universal vaccine against various flu viruses." ScienceDaily. www.sciencedaily.com/releases/2011/12/111208101756.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins