Featured Research

from universities, journals, and other organizations

Genetic predisposition to disease common in two supercentenarians

Date:
January 18, 2012
Source:
Boston University Medical Center
Summary:
The first-ever published whole-genome sequences of not just one, but two supercentenarians, aged more than 114 years, reveal that both unusual and common genetic phenomena contribute to the genetic background of extreme human longevity. Data from the study will be available to researchers around the world at the NIH data repository.

Both unusual and common genetic phenomena contribute to extreme human longevity according to a new study by BMC and Boston University Schools of Public Health and Medicine.

The study, published Jan. 3 in Frontiers in Genetics, reports a comprehensive analysis of the whole genome sequences of a man and a woman, both of whom lived past the age of 114. Supercentenarians (age 110+ years) are very rare, occurring at a rate of one person per five million in developed countries, and there is growing evidence supporting a strong genetic influence in survival to such ages.

The study shows that while the two supercentenarians carried as many disease-associated genes as the general population, their longevity suggests other protective mechanisms are at work.

The male subject had 37 genetic mutations associated with increased risk for colon cancer, indicating that he was in no way immune to that age-related disease. "In fact, he had presented with an obstructing colon cancer earlier in his life that had not metastasized and was cured with surgery. He was in phenomenal cognitive and physical shape near the time of his death," says Thomas Perls, MD, MPH, director of the New England Centenarian Study and senior author of the article.

The female supercentenarian also had numerous genetic variations associated with age-related diseases, including those related to increased risks for Alzheimer's, cancer and heart disease. She did have congestive heart failure and mild cognitive impairment, but these diseases did not become evident until after the age of 108 years.

"The presence of these disease-associated variants is consistent with our and other researchers' findings that centenarians carry as many disease-associated genes as the general population," Perls says. "The difference may be that the centenarians likely have longevity-associated variants that cancel out the disease genes. That effect may extend to the point that the diseases don't occur -- or, if they do, are much less pathogenic or markedly delayed toward the end of life, in these individuals who are practically living to the limit of the human lifespan."

"The study of these two supercentenarians is just the beginning, and genetic study of many more such subjects needs to be performed," adds Perls.

Data from the study will be available to researchers around the world at the National Institutes of Health (NIH) data repository.


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Paola Sebastiani, Alberto Riva, Monty Montano, Phillip Pham, Ali Torkamani, Eugene Scherba, Gary Benson, Jacqueline N. Milton, Clinton T. Baldwin, Stacy Andersen, Nicholas J. Schork, Martin H. Steinberg, Thomas T. Perls. Whole Genome Sequences of a Male and Female Supercentenarian, Ages Greater than 114 Years. Frontiers in Genetics, 2012; 2 DOI: 10.3389/fgene.2011.00090

Cite This Page:

Boston University Medical Center. "Genetic predisposition to disease common in two supercentenarians." ScienceDaily. ScienceDaily, 18 January 2012. <www.sciencedaily.com/releases/2012/01/120103135331.htm>.
Boston University Medical Center. (2012, January 18). Genetic predisposition to disease common in two supercentenarians. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2012/01/120103135331.htm
Boston University Medical Center. "Genetic predisposition to disease common in two supercentenarians." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103135331.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins