Featured Research

from universities, journals, and other organizations

New protein that plays part in arthritis discovered

Date:
January 5, 2012
Source:
Boise State University
Summary:
A new study has shed new light on how proteins interact, or bind, with one another in tissues. Biologists found that a protein called collagen XI interacts with specific proteins in the part of the tissue that provides structural support to the cell.

“Knowing which proteins collagen XI binds to could have significant implications in helping clinicians monitor cartilage health as well as diagnose and treat debilitating diseases like arthritis,” said study coauthor Julia Oxford, biology professor and director of the Biomolecular Research Center.
Credit: Image courtesy of Boise State University

A Boise State University study has shed new light on how proteins interact, or bind, with one another in tissues. The new information could help scientists with tissue engineering and strengthening efforts to treat cartilage damage and degeneration by diseases such as osteoarthritis, which affects more than 20 million Americans and is the most common type of arthritis.

Cartilage is central to proper growth and articulation of the joint. The cartilage tissue is composed of chondrocytes and a dense extracellular matrix, which in turn is composed of water, proteoglycans and collagens.

The Boise State biologists found that a protein called collagen XI interacts with specific proteins in the part of the tissue that provides structural support to the cell. Collagen XI is one of the few proteins that is known to prevent arthritis, and when it is mutated or absent, the individual will develop arthritis early in life. Even knowing this, the progression of the disease is still poorly understood by scientists. This lack of understanding prevents the development of effective treatments.

"Knowing which proteins collagen XI binds to could have significant implications in helping clinicians monitor cartilage health as well as diagnose and treat debilitating diseases like arthritis," said study coauthor Julia Oxford, biology professor and director of the Biomolecular Research Center. "Understanding these complex gene families will make major improvements in the quality of life for those dealing with a broad spectrum of arthritic syndromes. If we know what the structure should look like, we can look for changes caused by disease and figure out ways to stop and treat it."

The study appears online in the journal Proteomics.

To conduct the research, Boise State scientists studied tissue and used affinity chromatography and mass spectrometry to identify proteins that can interact with collagen XI. They found several molecules and cellular proteins that interact with it directly or indirectly, including proteoglycans and matricellular molecules, both of which play a significant role in tissue integrity and tissue development.

Oxford said based on their findings, collagen XI has the potential to be used as a diagnostic tool to predict which individuals are predisposed to the development of osteoarthritis.


Story Source:

The above story is based on materials provided by Boise State University. The original article was written by Matt Pene. Note: Materials may be edited for content and length.


Journal Reference:

  1. Raquel J. Brown, Christopher Mallory, Owen M. McDougal, Julia Thom Oxford. Proteomic analysis of Col11a1-associated protein complexes. Proteomics, 2011; 11 (24): 4660 DOI: 10.1002/pmic.201100058

Cite This Page:

Boise State University. "New protein that plays part in arthritis discovered." ScienceDaily. ScienceDaily, 5 January 2012. <www.sciencedaily.com/releases/2012/01/120105174222.htm>.
Boise State University. (2012, January 5). New protein that plays part in arthritis discovered. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/01/120105174222.htm
Boise State University. "New protein that plays part in arthritis discovered." ScienceDaily. www.sciencedaily.com/releases/2012/01/120105174222.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins