Featured Research

from universities, journals, and other organizations

Sensitive detection method analyzes circulating tumor cells in patients with lung cancer

Date:
January 9, 2012
Source:
American Association for Cancer Research
Summary:
Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies.

Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies.

"We have developed an extremely sensitive test that could be able to detect mutations present in circulating tumor cells (CTCs), and we are hoping that from their characterization, we would be able to understand diagnostic, prognostic and predictive markers," said Heidi S. Erickson, Ph.D., assistant professor of thoracic/head and neck medical oncology at the University of Texas MD Anderson Cancer Center.

Erickson presented the findings at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012.

Even though researchers have found that the presence of CTCs in the blood of patients with lung cancer is associated with short survival, clinicians have had no way to analyze the actual CTCs because their levels were so small.

In this study, Erickson and colleagues showed the effectiveness of using high-throughput matrix-assisted laser desorption/ionization time-of-flight mass spectrometry single nucleotide polymorphism analysis (MALDI-TOF MS SNP) -- an extremely sensitive analysis using a mass spectrometer -- to analyze and determine the exact genetic mutations present in DNA from a few malignant cells that can be applied to CTC samples.

Identifying these mutations would allow clinicians to track progress of genetic changes and thus monitor the cancer and the effectiveness of any treatments being administered. It could also enable researchers to identify ways in which the cancer develops and possibly identify new therapy targets. This analysis method also benefits the patient in the way samples are taken.

"By being able to collect a blood sample from a patient instead of having to do a biopsy, we'll have an opportunity to monitor the patient throughout treatment in an easier way," said Erickson.

The researchers showed the method works by "spiking" a blood sample with a cell line containing a known specific mutation. They then used the MALDI-TOF MS SNP method to test the sample and found the cancer cell line mutation they had used.

Collection and purification methods of CTC samples are not yet perfected. When they are, the researchers will test samples from actual patients with lung cancer, Erickson said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Sensitive detection method analyzes circulating tumor cells in patients with lung cancer." ScienceDaily. ScienceDaily, 9 January 2012. <www.sciencedaily.com/releases/2012/01/120109155714.htm>.
American Association for Cancer Research. (2012, January 9). Sensitive detection method analyzes circulating tumor cells in patients with lung cancer. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/01/120109155714.htm
American Association for Cancer Research. "Sensitive detection method analyzes circulating tumor cells in patients with lung cancer." ScienceDaily. www.sciencedaily.com/releases/2012/01/120109155714.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins