Featured Research

from universities, journals, and other organizations

'Good' HDL cholesterol can also be 'bad'

Date:
January 13, 2012
Source:
Medical University of Vienna
Summary:
Generally speaking, a distinction has been made so far between “good” HDL cholesterol and “bad” LDL cholesterol. LDL contributes to cardiovascular diseases such as myocardial infarction and stroke, while the “good” HDL protects against them. Now, however, experts have discovered that the anti-inflammatory effect of HDL was not detected in patients on renal dialysis.

Generally speaking, a distinction has been made so far between "good" HDL cholesterol and "bad" LDL cholesterol. LDL contributes to cardiovascular diseases such as myocardial infarction and stroke, while the "good" HDL protects against them. Now, however, experts at the MedUni Vienna have discovered that the anti-inflammatory effect of HDL was not detected in patients on renal dialysis. "In fact, the HDL amplified inflammatory reactions several times over and could explain the latent chronic inflammation that is associated with high cardiovascular risk," says Säemann.

On closer investigation of HDL levels in dialysis patients, i.e. people with renal failure, it was learned that levels of a specific molecule, known as serum amyloid A (SAA), were significantly raised in these individuals. SAA is a highly likely cause for the defect in the HDL. Says Weichhart: "If you integrate SAA into healthy HDL, it ceases to function properly."

Quality over quantity This discovery could change the evaluation of HDL cholesterol. Until now, a high level of HDL was regarded as ideal. "Much more important than the quantity, however, is of course the quality of the HDL. Non-functioning HDL cholesterol is useless -- even high HDL levels would cease to be healthy," says Weichhart. Explaining another finding, Säemann adds: "Lowering the LDL level is therefore still even more important than raising the HDL level."

It is currently not possible, however, to identify "bad" HDL quickly with a simple test. Weichhart and Säemann are currently working on the development of such a test. Together with the Medical University of Vienna, they have obtained a patent that will allow them to determine the changes in HDL using a simple laboratory test and therefore enable the risk of future cardiovascular disease to be estimated more accurately -- allowing treatment to be commenced sooner.

In recent years, it has been found that certain conditions such as coronary heart disease (CHD), diabetes mellitus and rheumatoid arthritis have their own, characteristic HDL. Some of the proteins that have just been discovered in the HDL of patients with renal failure have also been found in the HDL of these conditions, causing HDL to lose its beneficial, anti-inflammatory and vessel-protecting properties. "With the new laboratory test, we have now been able to investigate whether modified HDL is associated with a poorer prognosis in patients with renal failure at an early stage of their condition, and whether this is also the case for patients with diabetes or after a heart attack, for example. This would mean that a simple test principle would enable us to commence therapy early on, thereby decisively changing the overall prognosis for the better," say the MedUni Vienna researchers.


Story Source:

The above story is based on materials provided by Medical University of Vienna. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas Weichhart, Chantal Kopecky, Markus Kubicek, Michael Haidinger, Dominik Döller, Karl Katholnig, Cacang Suarna, Philipp Eller, Markus Tölle, Christopher Gerner, Gerhard J Zlabinger, Markus van der Giet, Walter H. Hörl, Roland Stocker, Marcus D Säemann. The proteomic signature of dysfunctional uremic HDL identifies SAA as proinflammatory component. Journal of the American Society of Nephrology, 2012

Cite This Page:

Medical University of Vienna. "'Good' HDL cholesterol can also be 'bad'." ScienceDaily. ScienceDaily, 13 January 2012. <www.sciencedaily.com/releases/2012/01/120113210207.htm>.
Medical University of Vienna. (2012, January 13). 'Good' HDL cholesterol can also be 'bad'. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2012/01/120113210207.htm
Medical University of Vienna. "'Good' HDL cholesterol can also be 'bad'." ScienceDaily. www.sciencedaily.com/releases/2012/01/120113210207.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) — Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins