Featured Research

from universities, journals, and other organizations

New discoveries in cell aging

Date:
January 23, 2012
Source:
Universitat Autònoma de Barcelona
Summary:
Researchers have quantified the effect of protein aggregation on the cell aging processes using as models the Escherichia coli bacteria and the molecule which is thought to trigger Alzheimer's disease. Scientists have demonstrated that the effect can be predicted before it occurs. Protein aggregation is related to several diseases, including neurodegenerative diseases. The research provides a reliable system with which to model and quantify the effect of protein aggregation on the viability, division and aging of cells. It also aids in the further understanding of proteins.

Structure of the peptide inducing Alzheimer's disease found in the bacteria used in the research.
Credit: Image courtesy of Universitat Autònoma de Barcelona

Researchers have quantified with precision the effect of protein aggregation on the cell aging processes using as models the Escherichia coli bacteria and the molecule which is thought to trigger Alzheimer's disease. Scientists have demonstrated that the effect can be predicted before it occurs. Protein aggregation is related to several diseases, including neurodegenerative diseases.

The research, published recently in the Journal of Molecular Biology, provides an extremely reliable system with which to model and quantify the effect of protein aggregation on the viability, division and aging of cells. It also aids in further understanding the natural evolution of proteins. According to Salvador Ventura, researcher at IBB and director of the research project, "it will serve to develop computer approximations to predict the effects aggregation has on cell aging, as well as to search for molecules that act as natural chaperones, highly conserved proteins which are present also in humans and which have the ability to reduce this effect in the bacteria."

Although it is widely accepted that bad folding and aggregation of proteins reduces the cell's ability to survive and reproduce, the damage caused had not been previously measured experimentally as precisely as it was in this research.

In previous studies scientists had verified that the expression of the Alzheimer's AB42 peptide in bacteria induces the process of protein aggregation. Now they have demonstrated that this effect is coded in the protein aggregation sequence and that it depends on intrinsic properties, not on a direct response from within the cell. This makes it possible to predict the effect. Scientists also demonstrated that damage caused to the bacteria is controlled by molecular chaperones, which reduce the tendency of proteins to aggregate and favour cell survival.

In addition to researchers from IBB and the UAB Department of Biochemistry and Molecular Biology, participating in the project were scientists from the Biophysics Unit at CSIC-UPV, the University of the Basque Country, the Institute for Bioengineering of Catalonia and the Barcelona Centre for International Health Research.


Story Source:

The above story is based on materials provided by Universitat Autònoma de Barcelona. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anna Villar-Pique, Natalia S. de Groot, Raimon Sabaté, Sergio P. Acebrón, Garbiñe Celaya, Xavier Fernàndez-Busquets, Arturo Muga, Salvador Ventura. The Effect of Amyloidogenic Peptides on Bacterial Aging Correlates with Their Intrinsic Aggregation Propensity. Journal of Molecular Biology, 2011; DOI: 10.1016/j.jmb.2011.12.014

Cite This Page:

Universitat Autònoma de Barcelona. "New discoveries in cell aging." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2012/01/120123101831.htm>.
Universitat Autònoma de Barcelona. (2012, January 23). New discoveries in cell aging. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/01/120123101831.htm
Universitat Autònoma de Barcelona. "New discoveries in cell aging." ScienceDaily. www.sciencedaily.com/releases/2012/01/120123101831.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins