Featured Research

from universities, journals, and other organizations

A single therapy slows multiple cancers

Date:
January 23, 2012
Source:
Rockefeller University Press
Summary:
Targeting a single protein can help fight both breast cancers and leukemias, according to two new reports.

Targeting a single protein can help fight both breast cancers and leukemias, according to two reports published online on January 23 in the Journal of Experimental Medicine.

The single protein is HSP90, which acts as a chaperone to protect other proteins in the cell.

A team led by Ute Moll at the University of Gφttingen in Germany found that blocking HSP90 activity rendered normally protected proteins vulnerable to attack and destruction. One of these proteins -- called migration inhibitory factor -- drives the growth of breast tumors. HSP90 inhibitors slowed the growth of MIF-expressing breast tumors in mice but had little effect on tumors lacking MIF.

HSP90 inhibitors also look promising for certain forms of leukemia, according to a study by David Weinstock and coworkers at the Dana-Farber Cancer Institute. They showed that HSP90 inhibitors slowed the growth of leukemias driven by hyperactive versions of the enzyme JAK2, many of which become resistant to JAK2-blocking drugs. The HSP90 inhibitors delayed the growth of resistant leukemia cells in mice.

Together these studies suggest that HSP90 may represent a therapeutic target in many cancers.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal References:

  1. R. Schulz, N. D. Marchenko, L. Holembowski, G. Fingerle-Rowson, M. Pesic, L. Zender, M. Dobbelstein, U. M. Moll. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. Journal of Experimental Medicine, 2012; DOI: 10.1084/jem.20111117
  2. O. Weigert, A. A. Lane, L. Bird, N. Kopp, B. Chapuy, D. van Bodegom, A. V. Toms, S. Marubayashi, A. L. Christie, M. McKeown, R. M. Paranal, J. E. Bradner, A. Yoda, C. Gaul, E. Vangrevelinghe, V. Romanet, M. Murakami, R. Tiedt, N. Ebel, E. Evrot, A. De Pover, C. H. Regnier, D. Erdmann, F. Hofmann, M. J. Eck, S. E. Sallan, R. L. Levine, A. L. Kung, F. Baffert, T. Radimerski, D. M. Weinstock. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. Journal of Experimental Medicine, 2012; DOI: 10.1084/jem.20111694

Cite This Page:

Rockefeller University Press. "A single therapy slows multiple cancers." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2012/01/120123123140.htm>.
Rockefeller University Press. (2012, January 23). A single therapy slows multiple cancers. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2012/01/120123123140.htm
Rockefeller University Press. "A single therapy slows multiple cancers." ScienceDaily. www.sciencedaily.com/releases/2012/01/120123123140.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins