Featured Research

from universities, journals, and other organizations

A single therapy slows multiple cancers

Date:
January 23, 2012
Source:
Rockefeller University Press
Summary:
Targeting a single protein can help fight both breast cancers and leukemias, according to two new reports.

Targeting a single protein can help fight both breast cancers and leukemias, according to two reports published online on January 23 in the Journal of Experimental Medicine.

Related Articles


The single protein is HSP90, which acts as a chaperone to protect other proteins in the cell.

A team led by Ute Moll at the University of Gφttingen in Germany found that blocking HSP90 activity rendered normally protected proteins vulnerable to attack and destruction. One of these proteins -- called migration inhibitory factor -- drives the growth of breast tumors. HSP90 inhibitors slowed the growth of MIF-expressing breast tumors in mice but had little effect on tumors lacking MIF.

HSP90 inhibitors also look promising for certain forms of leukemia, according to a study by David Weinstock and coworkers at the Dana-Farber Cancer Institute. They showed that HSP90 inhibitors slowed the growth of leukemias driven by hyperactive versions of the enzyme JAK2, many of which become resistant to JAK2-blocking drugs. The HSP90 inhibitors delayed the growth of resistant leukemia cells in mice.

Together these studies suggest that HSP90 may represent a therapeutic target in many cancers.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal References:

  1. R. Schulz, N. D. Marchenko, L. Holembowski, G. Fingerle-Rowson, M. Pesic, L. Zender, M. Dobbelstein, U. M. Moll. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. Journal of Experimental Medicine, 2012; DOI: 10.1084/jem.20111117
  2. O. Weigert, A. A. Lane, L. Bird, N. Kopp, B. Chapuy, D. van Bodegom, A. V. Toms, S. Marubayashi, A. L. Christie, M. McKeown, R. M. Paranal, J. E. Bradner, A. Yoda, C. Gaul, E. Vangrevelinghe, V. Romanet, M. Murakami, R. Tiedt, N. Ebel, E. Evrot, A. De Pover, C. H. Regnier, D. Erdmann, F. Hofmann, M. J. Eck, S. E. Sallan, R. L. Levine, A. L. Kung, F. Baffert, T. Radimerski, D. M. Weinstock. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. Journal of Experimental Medicine, 2012; DOI: 10.1084/jem.20111694

Cite This Page:

Rockefeller University Press. "A single therapy slows multiple cancers." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2012/01/120123123140.htm>.
Rockefeller University Press. (2012, January 23). A single therapy slows multiple cancers. ScienceDaily. Retrieved December 23, 2014 from www.sciencedaily.com/releases/2012/01/120123123140.htm
Rockefeller University Press. "A single therapy slows multiple cancers." ScienceDaily. www.sciencedaily.com/releases/2012/01/120123123140.htm (accessed December 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, December 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) — The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins