Featured Research

from universities, journals, and other organizations

Adult stem cells could improve angioplasy outcome; Study to explore usage

Date:
January 23, 2012
Source:
Creighton University
Summary:
A researcher is studying what role adult stem cells might play in repairing damaged coronary arteries, following angioplasty/stenting.

A Creighton University School of Medicine researcher has received a $3.3 million, five-year grant from the National Institutes of Health to study what role adult stem cells might play in repairing damaged coronary arteries, a complication that often occurs in patients after they undergo angioplasty and stenting.

Related Articles


"Restenosis, a re-narrowing of coronary arteries in the heart, after balloon angioplasty and the placement of stents, is a serious problem. Drug-eluting stents can help reduce the occurrence of restenosis. However, there is a serious tradeoff.

Drug-eluting stents can lead to thrombosis (platelet deposits in the endothelial lining around the blood vessels that destroy the lining), which then requires longer periods of anti-platelet therapy. This therapy, in turn, can produce serious side effects, including nosebleed, upset stomach, nausea and diarrhea," said Devendra Agrawal, Ph.D., principal investigator and a professor of biomedical sciences, internal medicine and medical microbiology and immunology.

For the study, Agrawal and his co-investigators, Creighton cardiologist Michael Del Core and pathologist William Hunter will deliver adult stem cells (autologous mesenchymal stem cells), together with a novel gene, at the site of an interventional procedure in the coronary arteries of a pig model.

The goal is to determine whether the administration of adult stem cells, along with the gene therapy, is superior to using drug-eluting stents following angioplasty, said Agrawal, holder of The Peekie Nash Carpenter Endowed Chair in Medicine. If successful, he added, the treatment could even eliminate the need for stents.

Recent research has shown that angioplasty and stenting -- commonly used to open narrowed coronary arteries -- are not as effective as once thought.

In fact, a study involving more than 15,000 patients and published Nov. 28 online by the Archives of Internal Medicine, shows that it can even do more harm than good in some patients. According to the study, nearly one in 10 patients undergoing coronary angioplasty was readmitted to a hospital within 30 days, and these patients were at higher risk of death within one year.

With angioplasty, a catheter-guided balloon is inserted to open a narrowed coronary artery. A wire mesh stent is typically implanted during the procedure to keep the artery open.

Eleven to18 percent of all patients experience restenosis or a re-narrowing of the artery within three-four years, said Agrawal.

This is the second grant Agrawal has received in recent months to explore alternatives to stenting. The first grant totaled $2.58 million over four years.


Story Source:

The above story is based on materials provided by Creighton University. Note: Materials may be edited for content and length.


Cite This Page:

Creighton University. "Adult stem cells could improve angioplasy outcome; Study to explore usage." ScienceDaily. ScienceDaily, 23 January 2012. <www.sciencedaily.com/releases/2012/01/120123133644.htm>.
Creighton University. (2012, January 23). Adult stem cells could improve angioplasy outcome; Study to explore usage. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2012/01/120123133644.htm
Creighton University. "Adult stem cells could improve angioplasy outcome; Study to explore usage." ScienceDaily. www.sciencedaily.com/releases/2012/01/120123133644.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins