Featured Research

from universities, journals, and other organizations

In schizophrenia research, a path to the brain through the nose

Date:
January 25, 2012
Source:
Elsevier
Summary:
A significant obstacle to progress in understanding psychiatric disorders is the difficulty in obtaining living brain tissue for study so that disease processes can be studied directly. Recent advances in basic cellular neuroscience now suggest that, for some purposes, cultured neural stem cells may be studied in order to research psychiatric disease mechanisms. But where can one obtain these cells outside of the brain?

A significant obstacle to progress in understanding psychiatric disorders is the difficulty in obtaining living brain tissue for study so that disease processes can be studied directly. Recent advances in basic cellular neuroscience now suggest that, for some purposes, cultured neural stem cells may be studied in order to research psychiatric disease mechanisms. But where can one obtain these cells outside of the brain?

Increasingly, schizophrenia research is turning to the nose. Strange as it may seem, the idea makes sense because the olfactory mucosa, the sense organ of smell in the nose, is continually regenerating new sensory neurons from "adult" stem cells. These neurons are among the very few nerve cells outside of the skull that connect directly to nerve cells in the brain.

Over several decades, researchers found that these cells can be collected directly by obtaining a small tissue sample, called a biopsy. By taking small pieces of olfactory tissue from the nose, researchers of this new study were able to gain access to the stem cells from patients with schizophrenia and compare them to cells from healthy individuals.

"We have discovered that patient cells proliferate faster -- they are running with a faster speed to their clock controlling the cell cycle -- and we have identified some of the molecules that are responsible," explained Dr. Alan Mackay-Sim from the National Centre for Adult Stem Cell Research in Brisbane, Australia, an author of the study. The findings clearly indicate that the natural cell cycle is dysregulated in individuals diagnosed with schizophrenia.

"This is a first insight into real differences in patient cells that could lead to slightly altered brain development," Mackay-Sim added. This is an important finding, as scientists are already aware of many developmental abnormalities in the 'schizophrenia brain'.

Dr. John Krystal, editor of Biological Psychiatry, commented: "The current findings are particularly interesting because when we look closely at the clues to the neurobiology of psychiatric disorders, we find new and often unexpected mechanisms implicated."


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yongjun Fan, Greger Abrahamsen, John J. McGrath, Alan Mackay-Sim. Altered Cell Cycle Dynamics in Schizophrenia. Biological Psychiatry, 2012; 71 (2): 129 DOI: 10.1016/j.biopsych.2011.10.004

Cite This Page:

Elsevier. "In schizophrenia research, a path to the brain through the nose." ScienceDaily. ScienceDaily, 25 January 2012. <www.sciencedaily.com/releases/2012/01/120125091153.htm>.
Elsevier. (2012, January 25). In schizophrenia research, a path to the brain through the nose. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/01/120125091153.htm
Elsevier. "In schizophrenia research, a path to the brain through the nose." ScienceDaily. www.sciencedaily.com/releases/2012/01/120125091153.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins