Featured Research

from universities, journals, and other organizations

Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies

Date:
March 5, 2012
Source:
University of Gothenburg
Summary:
Women who have eggs that cannot mature will not become pregnant, and they cannot be helped by in vitro fertilization (IVF). Now researchers have identified a molecule called Cdk1 that has an important function for mammalian egg maturation. In the future this could lead to an increased rate of successful IVF.

Women who have eggs that cannot mature will not become pregnant, and they cannot be helped by in vitro fertilization (IVF). Now researchers at the University of Gothenburg have identified a molecule called Cdk1 that has an important function for mammalian egg maturation. In the future this could lead to an increased rate of successful IVF.

Up to 15% of all women of reproductive age struggle to become pregnant. In vitro fertilization (IVF) can help these women become mothers. However, women who are infertile because their eggs do not mature properly cannot be helped medically, as immature eggs cannot be fertilized. In the future, such patients might be helped as a research group at the University of Gothenburg has found that the Cdk1 molecule has an important function in mammalian egg maturation. Their results have now been published in the journal Human Molecular Genetics.

"This is the first functional evidence that Cdk1 is a key molecule in mammalian egg maturation. If the results can be translated into clinical settings, it could possibly improve the chances of successful IVF treatment for women who today are not becoming pregnant because their eggs do not mature" says Kui Liu, professor at the Department of Chemistry and Molecular Biology, the University of Gothenburg, Sweden.

Kui Liu and his colleagues performed experiments on tissue-specific knockout mice. The results show that when the Cdk1 molecule was removed from eggs of mice, the egg maturation stopped. When the molecule was added again, maturation resumed.

Professor Liu is a professor in molecular biology at the Faculty of Science, University of Gothenburg, since February 2011. His research group specializes in studying the development of female germ cells. In the last few years he has been working on making his results useful for humans.

"We are eager to start tests on human eggs. Hopefully we can apply this in clinics within ten years" says Liu.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Adhikari, W. Zheng, Y. Shen, N. Gorre, G. Halet, P. Kaldis, K. Liu. Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes. Human Molecular Genetics, 2012; DOI: 10.1093/hmg/dds061

Cite This Page:

University of Gothenburg. "Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies." ScienceDaily. ScienceDaily, 5 March 2012. <www.sciencedaily.com/releases/2012/03/120305160658.htm>.
University of Gothenburg. (2012, March 5). Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/03/120305160658.htm
University of Gothenburg. "Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies." ScienceDaily. www.sciencedaily.com/releases/2012/03/120305160658.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins