Featured Research

from universities, journals, and other organizations

Nanotube technology leading to new era of fast, lower-cost medical diagnostics

Date:
March 9, 2012
Source:
Oregon State University
Summary:
Researchers have tapped into the extraordinary power of carbon "nanotubes" to increase the speed of biological sensors, a technology that might one day allow a doctor to routinely perform lab tests in minutes, speeding diagnosis and treatment while reducing costs. The new findings have almost tripled the speed of prototype nano-biosensors, and should find applications not only in medicine but in toxicology, environmental monitoring, new drug development and other fields.

Nanotube sensor. A carbon nanotube treated with a capture agent, in yellow, can bind with and detect the purple-colored target protein - this changes the electrical resistance of the nanotube and creates a sensing device.
Credit: Graphic courtesy of Oregon State University

Researchers at Oregon State University have tapped into the extraordinary power of carbon "nanotubes" to increase the speed of biological sensors, a technology that might one day allow a doctor to routinely perform lab tests in minutes, speeding diagnosis and treatment while reducing costs.

The new findings have almost tripled the speed of prototype nano-biosensors, and should find applications not only in medicine but in toxicology, environmental monitoring, new drug development and other fields.

The research was just reported in Lab on a Chip, a professional journal. More refinements are necessary before the systems are ready for commercial production, scientists say, but they hold great potential.

"With these types of sensors, it should be possible to do many medical lab tests in minutes, allowing the doctor to make a diagnosis during a single office visit," said Ethan Minot, an OSU assistant professor of physics. "Many existing tests take days, cost quite a bit and require trained laboratory technicians.

"This approach should accomplish the same thing with a hand-held sensor, and might cut the cost of an existing $50 lab test to about $1," he said.

The key to the new technology, the researchers say, is the unusual capability of carbon nanotubes. An outgrowth of nanotechnology, which deals with extraordinarily small particles near the molecular level, these nanotubes are long, hollow structures that have unique mechanical, optical and electronic properties, and are finding many applications.

In this case, carbon nanotubes can be used to detect a protein on the surface of a sensor. The nanotubes change their electrical resistance when a protein lands on them, and the extent of this change can be measured to determine the presence of a particular protein -- such as serum and ductal protein biomarkers that may be indicators of breast cancer.

The newest advance was the creation of a way to keep proteins from sticking to other surfaces, like fluid sticking to the wall of a pipe. By finding a way to essentially "grease the pipe," OSU researchers were able to speed the sensing process by 2.5 times.

Further work is needed to improve the selective binding of proteins, the scientists said, before it is ready to develop into commercial biosensors.

"Electronic detection of blood-borne biomarker proteins offers the exciting possibility of point-of-care medical diagnostics," the researchers wrote in their study. "Ideally such electronic biosensor devices would be low-cost and would quantify multiple biomarkers within a few minutes."

This work was a collaboration of researchers in the OSU Department of Physics, Department of Chemistry, and the University of California at Santa Barbara. A co-author was Vincent Remcho, professor and interim dean of the OSU College of Science, and a national expert in new biosensing technology.

The research was supported by the U.S. Army Research Laboratory through the Oregon Nanoscience and Microtechnologies Institute.


Story Source:

The above story is based on materials provided by Oregon State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matthew R. Leyden, Robert J. Messinger, Canan Schuman, Tal Sharf, Vincent T. Remcho, Todd M. Squires, Ethan D. Minot. Increasing the detection speed of an all-electronic real-time biosensor. Lab on a Chip, 2012; 12 (5): 954 DOI: 10.1039/C2LC21020G

Cite This Page:

Oregon State University. "Nanotube technology leading to new era of fast, lower-cost medical diagnostics." ScienceDaily. ScienceDaily, 9 March 2012. <www.sciencedaily.com/releases/2012/03/120309105607.htm>.
Oregon State University. (2012, March 9). Nanotube technology leading to new era of fast, lower-cost medical diagnostics. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2012/03/120309105607.htm
Oregon State University. "Nanotube technology leading to new era of fast, lower-cost medical diagnostics." ScienceDaily. www.sciencedaily.com/releases/2012/03/120309105607.htm (accessed September 19, 2014).

Share This



More Matter & Energy News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Virtual Reality Headsets Unveiled at Tokyo Game Show

Virtual Reality Headsets Unveiled at Tokyo Game Show

AFP (Sep. 18, 2014) Several companies unveiled virtual reality headsets at the Tokyo Game Show, Asia's largest digital entertainment exhibition. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Apple's iOS8 Includes New 'Killswitch' To Curb Theft

Apple's iOS8 Includes New 'Killswitch' To Curb Theft

Newsy (Sep. 18, 2014) Apple's new operating system, iOS 8, comes with Apple's killswitch feature already activated, unlike all the models before it. Video provided by Newsy
Powered by NewsLook.com
Stocks Hit All-Time High as Fed Holds Steady

Stocks Hit All-Time High as Fed Holds Steady

AP (Sep. 17, 2014) The Federal Reserve signaled Wednesday that it plans to keep a key interest rate at a record low because a broad range of U.S. economic measures remain subpar. Stocks hit an all-time high on the news. (Sept. 17) Video provided by AP
Powered by NewsLook.com
Space Race Pits Bezos Vs Musk

Space Race Pits Bezos Vs Musk

Reuters - Business Video Online (Sep. 16, 2014) Amazon CEO Jeff Bezos' startup will team up with Boeing and Lockheed to develop rocket engines as Elon Musk races to have his rockets certified. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins