Featured Research

from universities, journals, and other organizations

Neuronal transport granules: Single occupancy vehicles

Date:
March 26, 2012
Source:
University of Medicine and Dentistry of New Jersey (UMDNJ)
Summary:
Protein precursors destined for the spiny extensions of neurons travel single file, according to a new study.

Protein precursors destined for the spiny extensions of neurons travel single file, according to a study by Sanjay Tyagi, PhD, and colleagues at the University of Medicine and Dentistry of New Jersey (UMDNJ).

The study recently was published in Proceedings of the National Academy of Sciences.

Proteins involved in transmissions at the axon tips and synapses of neurons travel there in precursor form (known as messenger RNA, or mRNA) as cargo of a structure known as a transport granule. "The idea is that the mRNAs located at the synapse will be translated [into protein] on demand," explains Tyagi, an associate professor in the Department of Medicine at UMDNJ-New Jersey Medical School and at the school's Public Health Research Institute. "And if more than one copy of a protein is required on site," Tyagi adds, "it can be produced from a single mRNA."

Some investigators have suggested that these mRNAs carpool with others in the same granule. But the study by Tyagi and colleagues shows that these mRNAs proceed single file, with only one mRNA per granule. Although it may seem more efficient to transport multiple mRNAs in a single trip, this may not allow the neuron the flexibility it needs for the proper formation and functioning of synapses.

An increased understanding of how these mRNAs are transported to synapses may help scientists unravel the longstanding mystery behind memory generation, which requires the formation of new synapses and the modification of old ones.


Story Source:

The above story is based on materials provided by University of Medicine and Dentistry of New Jersey (UMDNJ). Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Batish, P. van den Bogaard, F. R. Kramer, S. Tyagi. Neuronal mRNAs travel singly into dendrites. Proceedings of the National Academy of Sciences, 2012; 109 (12): 4645 DOI: 10.1073/pnas.1111226109

Cite This Page:

University of Medicine and Dentistry of New Jersey (UMDNJ). "Neuronal transport granules: Single occupancy vehicles." ScienceDaily. ScienceDaily, 26 March 2012. <www.sciencedaily.com/releases/2012/03/120326132543.htm>.
University of Medicine and Dentistry of New Jersey (UMDNJ). (2012, March 26). Neuronal transport granules: Single occupancy vehicles. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2012/03/120326132543.htm
University of Medicine and Dentistry of New Jersey (UMDNJ). "Neuronal transport granules: Single occupancy vehicles." ScienceDaily. www.sciencedaily.com/releases/2012/03/120326132543.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins