Featured Research

from universities, journals, and other organizations

New clues to development of blood and other cancers

Date:
April 2, 2012
Source:
Fox Chase Cancer Center
Summary:
Scientists have uncovered more details about how defects in components of the machinery that makes new proteins can lead to blood and other cancers.

Scientists at Fox Chase Cancer Center have uncovered more details about how defects in components of the machinery that makes new proteins can lead to blood and other cancers. The findings, presented at the AACR Annual Meeting 2012 on April 2, may one day lead to new targeted therapies that address those problems.

Related Articles


"These findings help explain how mutations in one class of proteins can trigger the development of cancer," says Shuyun Rao, PhD, a scientific associate in the lab of David L. Wiest, PhD, also a co-author on the study, at Fox Chase Cancer Center in Philadelphia. "If we find a way to block the pathway activated by these mutations, this may cause tumors to regress."

The research focused specifically on ribosomal proteins. Previous research has linked mutations in ribosomal proteins to cancers such as leukemia and lymphoma, as well as myelodysplastic syndromes (MDS), which can lead to acute myelogenous leukemia (AML). However, this study represents the first insights into how mutations in ribosomal proteins might increase cancer risk.

To investigate further how an individual ribosomal protein might trigger cancer, Rao, Wiest and their colleagues focused on one known as L22. To begin, they looked at blood samples from a small number of leukemia patients -- approximately 50 -- and found that in 9%, L22 was either mutated or deleted entirely. This suggested that problems in L22 may have played a role in the development of their cancers.

Next, they deleted L22 in mice that were bred to be prone to develop lymphomas, and saw that their tumors developed faster, and the mice died faster than those who had intact forms of L22 -- further evidence of its important role in the disease.

Finally, in a sample of cells in the lab, the researchers inactivated L22 and saw that the cells experienced changes, signaling the early stages of lymphoma. Specifically, cells without L22 showed more activity in a pathway associated with inflammation known as NFkappaB, which other research has linked to cancer. "In theory, if we could find a way to block this pathway, we could add this to existing therapies to help treat the tumors it triggers," says Rao.

Although L22 is a ribosomal protein, and therefore helps build new proteins, previous research has found that eliminating L22 does not affect the rate with which cells make new proteins -- suggesting L22 has additional functions, says Rao.

Previous research has found that L22 expression is strikingly reduced in a number of liquid and solid tumors including breast cancer, lung adenocarcinoma and ovarian carcinoma. "These findings don't just have implications for people with leukemia," Wiest says. "It is likely that L22 repression or inactivation will play a role in other cancer types as well"

Co-authors on the study include researchers at Fox Chase, Dana-Farber Cancer Institute in Boston, Massachusetts; St. Jude Children's Research Hospital in Memphis, Tennessee; and the University of Colorado Denver School of Medicine in Aurora, Colorado.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "New clues to development of blood and other cancers." ScienceDaily. ScienceDaily, 2 April 2012. <www.sciencedaily.com/releases/2012/04/120402094156.htm>.
Fox Chase Cancer Center. (2012, April 2). New clues to development of blood and other cancers. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2012/04/120402094156.htm
Fox Chase Cancer Center. "New clues to development of blood and other cancers." ScienceDaily. www.sciencedaily.com/releases/2012/04/120402094156.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins