Featured Research

from universities, journals, and other organizations

New hormone for lowering blood sugar

Date:
April 3, 2012
Source:
Cell Press
Summary:
New evidence points to a hormone that leaves muscles gobbling up sugar as if they can't get enough. That factor, which can be coaxed out of fat stem cells, could lead to a new treatment to lower blood sugar and improve metabolism, according to a new report.

New evidence points to a hormone that leaves muscles gobbling up sugar as if they can't get enough. That factor, which can be coaxed out of fat stem cells, could lead to a new treatment to lower blood sugar and improve metabolism, according to a report in the April issue of Cell Metabolism, a Cell Press publication.

This new fat-derived hormone would appear to be a useful alternative or add-on to insulin; it can do essentially the same job, sending glucose out of the bloodstream and into muscle.

"It's like you've opened the door and now the glucose can come in," said Jonathan Graff of the University of Texas Southwestern Medical Center.

Graff's team manipulated a key developmental pathway in the fat stem cells of mice to find that the animals showed remarkably low blood sugar levels. The animals' muscles were taking up glucose at two to four times the usual rate thanks to an abundance of glucose transporters at their surfaces. That discovery was all the more striking because the animals also lacked fat stores, a condition known as lipodystrophy that normally results in just the opposite: high blood sugar and diabetes.

The mice could respond normally to insulin, but insulin surprisingly had nothing to do with the muscles' unusual appetite for sugar. The source for the change wasn't anything inherently different in the muscle itself either; it was something about those manipulated fat stem cells.

Further experiments revealed that the mouse muscles continued to take up extra sugar when they were isolated in the lab and exposed to blood serum. "It showed these effects were likely secondary to blood-borne signals sent by the manipulated fat cell progenitors," Graff says.

That signal can be generated only by fat stem cells, not mature fat cells. When the researchers made the same developmental manipulation in adult fat cells, they saw no such effect on blood sugar or muscle.

The findings highlight a new fat to muscle hormonal cue that would seem to have real therapeutic promise.

"If we can purify this factor and give it to people, there is potential for its use to lower and help control blood sugar," Graff says. Alternatively, there might be a way to encourage fat stem cells in the body to produce more of the anti-diabetic factor themselves.

Zeve et al.: "Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zeve et al. Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metabolism, 2012 DOI: 10.1016/j.cmet.2012.03.010

Cite This Page:

Cell Press. "New hormone for lowering blood sugar." ScienceDaily. ScienceDaily, 3 April 2012. <www.sciencedaily.com/releases/2012/04/120403124352.htm>.
Cell Press. (2012, April 3). New hormone for lowering blood sugar. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/04/120403124352.htm
Cell Press. "New hormone for lowering blood sugar." ScienceDaily. www.sciencedaily.com/releases/2012/04/120403124352.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins