Featured Research

from universities, journals, and other organizations

Cellular pathway linked to diabetes, heart disease

Date:
April 19, 2012
Source:
University of Cincinnati Academic Health Center
Summary:
Cardiac researchers have found that a certain cellular pathway is linked to obesity-related disorders, like diabetes, heart disease and fatty liver disease.

Cardiac researchers at the University of Cincinnati have found that a certain cellular pathway is linked to obesity-related disorders, like diabetes, heart disease and fatty liver disease.

Related Articles


These findings, being presented at the American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) 2012 Scientific Sessions in Chicago, April 19, 2012, could lead to a potential molecular target for metabolic diseases in humans.

Building on previous research, Tapan Chatterjee, PhD, and researchers in the division of cardiovascular diseases at UC found that genetically "deleting" the enzyme histone deacetylase 9 (HDAC9) completely protected mice against the health consequences of high-fat feeding, like elevated blood sugar, cholesterol levels and fatty liver disease.

Chatterjee says HDAC9 has been found to lead to obesity-induced body fat dysfunction.

"Failure of fat cells to differentiate and properly store excess calories in obesity is associated with adipose tissue (fat) inflammation, fatty liver disease, insulin resistance, diabetes and increased cardiovascular diseases," he says. "We know that dysfunctional fat tissue is the underlying culprit in obesity-related diseases.

"Caloric intake promotes HDAC9 down-regulation to allow the conversion of precursor fat cells to 'functional' fat cells, capable of efficiently storing excess calories for future use and also maintaining whole-body lipid and glucose stability," Chatterjee continues. "Unfortunately, during chronic over-feeding, the HDAC9 level is up-regulated in fat tissue, thereby blocking the conversion which leads to adipose tissue dysfunction and the onset of diseases such as diabetes, liver disease, high blood pressure and heart disease -- the nation's No. 1 killer."

Chatterjee says that in previous studies, researchers found that elevated HDAC9 expression in fat cells was the underlying molecular culprit for dysfunctional fat tissue during obesity.

"In this study, we used 'knockout' mouse models to test this theory," he says. "Deleting the HDAC9 gene completely prevented mice from developing obesity-related diseases during chronic high-fat feeding. These results mean the discovery of a potential molecular culprit in obesity-related disease development."

Chatterjee says emerging evidence from his laboratory indicates that unhealthy dietary habits over a long period of time promote specific changes in a human's epigenetic structure -- meaning changes in the gene structure that influences its function -- to switch HDAC9 expression to a higher level.

"This switch paves the way for development of a chronic disease state, despite subsequent dietary intervention," he says. "We are currently focusing our attention to design drugs to reverse such epigenetic changes to bring HDAC9 expression down and restore normal fat cell function in obese individuals, representing a novel treatment strategy for obesity-related disease conditions." . This study was funded by a grant from the National Heart Lung and Blood Institute.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. The original article was written by Katie Pence. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati Academic Health Center. "Cellular pathway linked to diabetes, heart disease." ScienceDaily. ScienceDaily, 19 April 2012. <www.sciencedaily.com/releases/2012/04/120419132604.htm>.
University of Cincinnati Academic Health Center. (2012, April 19). Cellular pathway linked to diabetes, heart disease. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2012/04/120419132604.htm
University of Cincinnati Academic Health Center. "Cellular pathway linked to diabetes, heart disease." ScienceDaily. www.sciencedaily.com/releases/2012/04/120419132604.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins