Featured Research

from universities, journals, and other organizations

Genes that increase the risk of osteoporosis and fractures discovered

Date:
April 23, 2012
Source:
University of Gothenburg
Summary:
Researchers have identified the genetic variations that are believed to cause osteoporosis. The study shows among other interesting facts that women with a higher proportion of genetic variations associated with osteoporosis have a more than 50 percent increased fracture risk.

Researchers at the Sahlgrenska Academy have identified the genetic variations that are believed to cause osteoporosis. The study, published in Nature Genetics and involving leading researchers from Sweden and the world, shows among other interesting facts that women with a higher proportion of genetic variations associated with osteoporosis have a more than 50 percent increased fracture risk.

Related Articles


Osteoporosis is a common and a devastating age-related disease about 50 percent of all who have a hip fracture after age 80 die within one year from the time of injury. The consequences of osteoporosis are therefore well-known, but the causes of the disease are largely unknown.

56 genetic regions for bone density

In a groundbreaking international study, which is led partially from the Sahlgrenska Academy, researchers have now succeeded in identifying a total of 56 genetic regions that control bone density in human beings. Fourteen of these genetic variants increase the risk of fractures, the study, which has been published in the world-leading journal Nature Genetics, has shown.

"This is the first time anyone has identified the genetic variants that are so strongly associated with an increased risk of fracture," comments Claes Ohlsson, a professor at the Sahlgrenska Academy.

Study on 80,000 people

"We can prove that women who have a large number of genetic variants associated with low bone density have up to a 56 percent higher risk of osteoporosis as compared with women who have a normal set-ups of the same genetic variants," comments Claes Ohlsson.

Targets for new treatment methods

The results have led to several new findings in bone biology, among other things the researchers identified several important molecular signaling pathways for bone density that can be targets for new treatment methods and therapies.

"In addition to already known proteins and pathways that were confirmed by the study, we are now facing a whole new biology in the field of bone research," comments Ulrika Pettersson, Associate Professor in the Department of Pharmacology and Clinical Neuroscience, Umeε University, and co-author of the study.

The article "Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with the risk of fracture" has been published in Nature Genetics on 15 April.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "Genes that increase the risk of osteoporosis and fractures discovered." ScienceDaily. ScienceDaily, 23 April 2012. <www.sciencedaily.com/releases/2012/04/120423132011.htm>.
University of Gothenburg. (2012, April 23). Genes that increase the risk of osteoporosis and fractures discovered. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2012/04/120423132011.htm
University of Gothenburg. "Genes that increase the risk of osteoporosis and fractures discovered." ScienceDaily. www.sciencedaily.com/releases/2012/04/120423132011.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) — Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) — Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) — Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) — Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins