Featured Research

from universities, journals, and other organizations

Gene that plays key role in inheritance (FANCM) identified

Date:
April 30, 2012
Source:
Helmholtz Association of German Research Centres
Summary:
Scientists have identified relevant new functions of a gene that plays a crucial role in Fanconi anemia, a life-threatening disease. The FANCM gene is known to be important for the stability of the genome. Now, the researchers found that FANCM also plays a key role in the recombination of genetic information during inheritance.

Leptotene stage during the meiosis of germ cells in thale cress: Halving of the number of the chromosomes is accompanied by a recombination of hereditary information.
Credit: Botanical Institute II, KIT

Scientists of KIT and the University of Birmingham have identified relevant new functions of a gene that plays a crucial role in Fanconi anemia, a life-threatening disease. The FANCM gene is known to be important for the stability of the genome. Now, the researchers found that FANCM also plays a key role in the recombination of genetic information during inheritance. For their studies, the scientists used thale cress as a model plant.

Related Articles


Their results are newly published by the journal The Plant Cell.

Stability of the genome is ensured by a series of mechanisms. If these are lacking, the risk of cancer and other severe diseases is increased. Fanconi anemia is a recessive hereditary disease associated with dysplasia, degeneration of bone marrow, and an increased risk of leukemia and tumors. FANCM is one of the genes responsible for Fanconi anemia. So far, the deactivation of FANCM has been known to lead to genome instability in somatic cells, i.e. body cells that are not involved in reproduction. "We have now proven that FANCM does not only ensure genome stability in somatic cells, but also controls inheritance," explains Dr. Alexander Knoll from the Botanical Institute II of KIT, first author of the publication in The Plant Cell.

According to the findings, FANCM plays a key role in the combination of paternal and maternal traits in the germ cells. The gene can be detected in nearly all organisms, from bacteria to yeast to plants to man. For their studies, the researchers from Karlsruhe and Birmingham used thale cress (Arabidopsis thaliana) as a model organism. The genome of this plant belonging to the family of cruciferous plants is relatively small and completely sequenced. The researchers found that the FANCM-homologous gene At-FANCM ensures ordered distribution and recombination of the genetic material during the meiosis of the germ cells in thale cress. "These findings cannot only be applied in biomedicine, but also in plant breeding in order to specifically improve the properties of usable crops," explains the Head of the Botanical Institute II of KIT, Professor Holger Puchta.


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexander Knoll, James D. Higgins, Katharina Seeliger, Sarah J. Reha, Natalie J. Dangel, Markus Bauknecht, Susan Schrφpfer, F. Christopher H. Franklin, Holger Puchta. The fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis thaliana. Plant Cell, April 30, 2012 DOI: 10.1105/tpc.112.096644

Cite This Page:

Helmholtz Association of German Research Centres. "Gene that plays key role in inheritance (FANCM) identified." ScienceDaily. ScienceDaily, 30 April 2012. <www.sciencedaily.com/releases/2012/04/120430105353.htm>.
Helmholtz Association of German Research Centres. (2012, April 30). Gene that plays key role in inheritance (FANCM) identified. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2012/04/120430105353.htm
Helmholtz Association of German Research Centres. "Gene that plays key role in inheritance (FANCM) identified." ScienceDaily. www.sciencedaily.com/releases/2012/04/120430105353.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) — Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) — Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) — One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins