Featured Research

from universities, journals, and other organizations

Evidence that BMI has an independent and causal effect on heart disease risk

Date:
May 1, 2012
Source:
University of Bristol
Summary:
In addition to the many risk factors associated with poor health, reducing body mass index (BMI) will have a considerable and independent impact if you want to reduce the risk of developing ischemic heart disease. This is the key finding from new research which evaluated the causal relationship between BMI and heart disease in 76,000 individuals.

In addition to the many risk factors associated with poor health, reducing body mass index (BMI) will have a considerable and independent impact if you want to reduce the risk of developing ischemic heart disease (IHD). This is the key finding from new research, published in PLoS Medicine, which evaluated the causal relationship between BMI and heart disease in 76,000 individuals.

BMI, alongside age, smoking, diabetes, high blood pressure, high blood cholesterol levels, and individuals who have family history of the disease, has been long recognised as a risk factor for heart disease. Despite this, the actual causal contribution of BMI to disease risk has been difficult to quantify.

New findings from a collaborative effort between the Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology (CAiTE) at the University of Bristol and colleagues from Copenhagen University Hospital, have revealed that an elevation in BMI of around 4kg/m2 across the life-course will increase the risk of developing the disease by 50 per cent on average.

Using genetic data from three large Danish studies -- the Copenhagen General Population Study, the Copenhagen City Heart Study and the Copenhagen Ischemic Heart Disease Study -- the researchers were able to use genetic variation known to be related to BMI to measure the true causal effect between this and IHD.

In observational estimates, the researchers found that for every 4 kg increase in BMI a 26 per cent increase in odds for developing IHD, while causal analysis identified a 52 per cent increase.

Dr Timpson, Lecturer in Genetic Epidemiology from the University's School of Social and Community Medicine, said: "In light of rising obesity levels, these findings are fundamental to improving public health. Our research shows that shifting to a lifestyle that promotes a lower BMI (even if it does nothing else) will reduce the odds of developing the disease."

Professor Børge Nordestgaard, lead author of the study from the University of Copenhagen, added: "These findings are of key importance, as obesity linked to diabetes is the only major cardiovascular risk factor on the rise in North America and Europe, while smoking, cholesterol levels and hypertension have been decreasing."


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. Børge G. Nordestgaard, Tom M. Palmer, Marianne Benn, Jeppe Zacho, Anne Tybjærg-Hansen, George Davey Smith, Nicholas J. Timpson. The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach. PLoS Medicine, 2012; 9 (5): e1001212 DOI: 10.1371/journal.pmed.1001212

Cite This Page:

University of Bristol. "Evidence that BMI has an independent and causal effect on heart disease risk." ScienceDaily. ScienceDaily, 1 May 2012. <www.sciencedaily.com/releases/2012/05/120501183017.htm>.
University of Bristol. (2012, May 1). Evidence that BMI has an independent and causal effect on heart disease risk. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2012/05/120501183017.htm
University of Bristol. "Evidence that BMI has an independent and causal effect on heart disease risk." ScienceDaily. www.sciencedaily.com/releases/2012/05/120501183017.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) — A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) — A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) — A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins