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Let's get moving: Unraveling how locomotion starts

Date:
May 16, 2012
Source:
University of Bristol
Summary:
Scientists have shed new light on one of the great unanswered questions of neuroscience: How the brain initiates rhythmic movements like walking, running and swimming.

The Xenopus frog tadpole is a small, simple vertebrate.
Credit: Image courtesy of University of Bristol

Scientists at the University of Bristol have shed new light on one of the great unanswered questions of neuroscience: how the brain initiates rhythmic movements like walking, running and swimming.

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While experiments in the 1970s using electrical brain stimulation identified areas of the brain responsible for starting locomotion, the precise neuron-by-neuron pathway has not been described in any vertebrate -- until now.

To find this pathway, Dr Edgar Buhl and colleagues in Bristol's School of Biological Sciences studied a small, simple vertebrate: the Xenopus frog tadpole.

They found that the pathway to initiate swimming consists of just four types of neurons. By touching skin on the head of the tadpole and applying cellular neurophysiology and anatomy techniques, the scientists identified nerve cells that detect the touch on the skin, two types of brain nerve cells which pass on the signal, and the motor nerve cells that control the swimming muscles.

Dr Buhl said: "These findings address the longstanding question of how locomotion is initiated following sensory stimulation and, for the first time in any vertebrate, define in detail a direct pathway responsible. They could thus be of great evolutionary interest and could also open the path to understanding initiation of locomotion in other vertebrates."

When mechanisms in the brain that initiate locomotion break down -- for example, in people with Parkinson's disease -- starting to walk becomes a real problem. Therefore, understanding the initiation of swimming in tadpoles could be a first step towards understanding the initiation of locomotion in more complex vertebrates, including people, and may eventually have implications for treating movement disorders such as Parkinson's.

The research is published in the Journal of Physiology.


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. Edgar Buhl, Alan Roberts, Stephen R. Soffe. The role of a trigeminal sensory nucleus in the initiation of locomotion. The Journal of Physiology, 2012; DOI: 10.1113/jphysiol.2012.227934

Cite This Page:

University of Bristol. "Let's get moving: Unraveling how locomotion starts." ScienceDaily. ScienceDaily, 16 May 2012. <www.sciencedaily.com/releases/2012/05/120516115908.htm>.
University of Bristol. (2012, May 16). Let's get moving: Unraveling how locomotion starts. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2012/05/120516115908.htm
University of Bristol. "Let's get moving: Unraveling how locomotion starts." ScienceDaily. www.sciencedaily.com/releases/2012/05/120516115908.htm (accessed October 30, 2014).

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