Featured Research

from universities, journals, and other organizations

Potential new drugs for fox tapeworm infection in humans

Date:
May 16, 2012
Source:
American Chemical Society
Summary:
Scientists are reporting development and testing of a new series of drugs that could finally stop the fox tapeworm -- which causes a rare but life-threatening disease in humans -- dead in its tracks. The report shows that specific organometallic substances that help combat cancer are also the surprising best new hope for a treatment against tapeworm infection.

Scientists are reporting development and testing of a new series of drugs that could finally stop the fox tapeworm
Credit: Image courtesy of American Chemical Society

Scientists are reporting development and testing of a new series of drugs that could finally stop the fox tapeworm -- which causes a rare but life-threatening disease in humans -- dead in its tracks. The report, which appears in ACS' Journal of Medicinal Chemistry, shows that specific organometallic substances that help combat cancer are also the surprising best new hope for a treatment against tapeworm infection.

Carsten Vock, Andrew Hemphill and colleagues explain that alveolar echinococcosis (AE) is a parasitic disease caused by the fox tapeworm Echinococcus multilocularis. Although rare, AE disease results in the death of about 94 percent of patients worldwide within 10-20 years of diagnosis if not treated appropriately. Most infections occur in the Northern hemisphere, in places like central Asia, northwestern China, and parts of Japan and Europe. People become infected from eating food contaminated with the parasite's eggs, which are found in the feces of infected foxes, cats or dogs.

Surgery is considered the best option for AE patients, but it does not always remove all of the parasites. Current AE drugs do not cure the disease, but simply keep the parasites at bay. These medicines must be taken life-long. In AE patients, the tapeworms cause tumor-like growths, which can metastasize or spread to different parts of the body. This reminded the researchers of cancer, so they looked at whether ruthenium complexes, promising anti-cancer agents, could also treat tapeworm.

The group prepared and evaluated several ruthenium complexes as potential drugs against the fox tapeworm. Some were effective in killing the tapeworms and also were less toxic on normal cells in laboratory dish tests, making them prime candidates for further development as treatments for AE.

The authors acknowledge funding from the Swiss National Science Foundation, the Bangerter Rhyner Foundation, the Swiss Life Foundation and Fondation Sana.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tatiana Kόster, Nadine Lense, Fabienne Barna, Andrew Hemphill, Markus K. Kindermann, Joachim W. Heinicke, Carsten A. Vock. A New Promising Application for Highly Cytotoxic Metal Compounds: η6-Areneruthenium(II) Phosphite Complexes for the Treatment of Alveolar Echinococcosis. Journal of Medicinal Chemistry, 2012; 55 (9): 4178 DOI: 10.1021/jm300291a

Cite This Page:

American Chemical Society. "Potential new drugs for fox tapeworm infection in humans." ScienceDaily. ScienceDaily, 16 May 2012. <www.sciencedaily.com/releases/2012/05/120516140113.htm>.
American Chemical Society. (2012, May 16). Potential new drugs for fox tapeworm infection in humans. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2012/05/120516140113.htm
American Chemical Society. "Potential new drugs for fox tapeworm infection in humans." ScienceDaily. www.sciencedaily.com/releases/2012/05/120516140113.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) — The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) — A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) — The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) — The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins