Featured Research

from universities, journals, and other organizations

Discovery promises unique medicine for treatment of chronic and diabetic wounds

Date:
May 28, 2012
Source:
Ume universitet
Summary:
A unique new medicine that can start and accelerate healing of diabetic and other chronic wounds is now being developed. After several years of successful experimental research, it is now ready for clinical testing.

A unique new medicine that can start and accelerate healing of diabetic and other chronic wounds is being developed at Ume University in Sweden. After several years of successful experimental research, it is now ready for clinical testing.

Related Articles


Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a key-regulator that initiates and accelerates wound healing by triggering the inflammatory reaction. Their discovery is now being published in the journal Blood.

“Today we have the knowledge needed to develop a medicine,” says Professor Tor Ny, one of the authors of the article. “The bulk of the preclinical research has been completed, and we have had meetings with the Medical Product Agency to discuss a program for clinical testing.”

Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Ume researchers have now re-assessed its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic wounds the level of plasminogen does not increase in the same way, and this seems to be the reason why these wounds do not heal. In diabetic mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected around the wound, which then heals fully.

A cell line for producing plasminogen on a larger scale has also been developed, and the goal is to start clinical testing as soon as funding can be arranged. The researchers have high hopes, as plasminogen is an endogenous protein that can be assumed not to produce side effects.

The need for a biologics for treating chronic wounds is urgent. Diabetic wounds that do not heal are the most severe type of chronic wounds, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Today’s treatment of diabetic wounds consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.

The Ume researchers are initially concentrating on diabetic wounds, but plasminogen also has great potential for working on other types of wounds. This includes tympanic membrane perforations and periodontitis. Being a pro-inflammatory activator, plasminogen has moreover been shown to be effective in combating antibiotic-resistant bacteria (MRSA).


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Shen, Y. Guo, P. Mikus, R. Sulniute, M. Wilczynska, T. Ny, J. Li. Plasminogen is a key pro-inflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood, 2012; DOI: 10.1182/blood-2012-01-407825

Cite This Page:

Ume universitet. "Discovery promises unique medicine for treatment of chronic and diabetic wounds." ScienceDaily. ScienceDaily, 28 May 2012. <www.sciencedaily.com/releases/2012/05/120528100242.htm>.
Ume universitet. (2012, May 28). Discovery promises unique medicine for treatment of chronic and diabetic wounds. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2012/05/120528100242.htm
Ume universitet. "Discovery promises unique medicine for treatment of chronic and diabetic wounds." ScienceDaily. www.sciencedaily.com/releases/2012/05/120528100242.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins