Featured Research

from universities, journals, and other organizations

Protein in saliva promises new diagnostic methods

Date:
May 31, 2012
Source:
Expertanswer
Summary:
Blood poisoning is a serious problem in medical care. New research now shows that the protein suPAR, which can be used for early detection of critical cases of sepsis, is found in saliva, which opens new potential for tracking diseases.

Blood poisoning is a serious problem in medical care. Research from Malmφ University in Sweden now shows that the protein suPAR, which can be used for early detection of critical cases of sepsis, is found in saliva, which opens new potential for tracking diseases.

Blood poisoning, or sepsis, affects about 0.2 percent of the population. It is a serious condition that can lead to septic shock, one of the most common causes of death at Swedish intensive care units. There is therefore a great need for early identification of potentially critical cases among patients.

SuPAR a good marker

The protein suPAR can be used as a marker of blood poisoning. This is shown in a dissertation written by Anna Gustafsson, a doctoral candidate at Malmφ University. Gustafsson also found that the protein correlates with the so-called SOFA score, a measure of organ failure that is used in cases of blood poisoning. The protein could thus be used to identify patients who risk developing serious disease.

"Today a number of analyses are put together to identify these patients. It would be much easier and quicker to use suPAR, because only one sample is needed," she says.

Opens new avenues

Gustafsson is also the first researcher to study the occurrence of suPAR in saliva and has found that the concentration of the protein is ten times higher than in the blood.

"We know that saliva reflects the composition of blood. The fact that suPAR in the blood can indicate cancer, diabetes, and other serious diseases means that our findings could open entirely new avenues for tracking various diseases in saliva," says Gustafsson.

Using saliva instead of blood samples is of great value in screening studies, as samples can be acquired with little bother to patients, who in fact can take the sample themselves at home.

Treatment with peptides

Medical care needs not only better diagnostic methods but also more effective treatment for blood poisoning. In her research Gustafsson has studied how antimicrobial peptides, AMPs, affect two different bacterial toxins, LPS and LTA.

"The results show that AMPs moderate the immune defense's reaction to LPS but strengthen the reaction to LTA. This is a truly unexpected finding, which hypothetically could mean that peptide treatment of LTA might aggravate the condition," says Gustafsson.


Story Source:

The above story is based on materials provided by Expertanswer. Note: Materials may be edited for content and length.


Cite This Page:

Expertanswer. "Protein in saliva promises new diagnostic methods." ScienceDaily. ScienceDaily, 31 May 2012. <www.sciencedaily.com/releases/2012/05/120531101901.htm>.
Expertanswer. (2012, May 31). Protein in saliva promises new diagnostic methods. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2012/05/120531101901.htm
Expertanswer. "Protein in saliva promises new diagnostic methods." ScienceDaily. www.sciencedaily.com/releases/2012/05/120531101901.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins