Featured Research

from universities, journals, and other organizations

Protein in saliva promises new diagnostic methods

Date:
May 31, 2012
Source:
Expertanswer
Summary:
Blood poisoning is a serious problem in medical care. New research now shows that the protein suPAR, which can be used for early detection of critical cases of sepsis, is found in saliva, which opens new potential for tracking diseases.

Blood poisoning is a serious problem in medical care. Research from Malmö University in Sweden now shows that the protein suPAR, which can be used for early detection of critical cases of sepsis, is found in saliva, which opens new potential for tracking diseases.

Related Articles


Blood poisoning, or sepsis, affects about 0.2 percent of the population. It is a serious condition that can lead to septic shock, one of the most common causes of death at Swedish intensive care units. There is therefore a great need for early identification of potentially critical cases among patients.

SuPAR a good marker

The protein suPAR can be used as a marker of blood poisoning. This is shown in a dissertation written by Anna Gustafsson, a doctoral candidate at Malmö University. Gustafsson also found that the protein correlates with the so-called SOFA score, a measure of organ failure that is used in cases of blood poisoning. The protein could thus be used to identify patients who risk developing serious disease.

"Today a number of analyses are put together to identify these patients. It would be much easier and quicker to use suPAR, because only one sample is needed," she says.

Opens new avenues

Gustafsson is also the first researcher to study the occurrence of suPAR in saliva and has found that the concentration of the protein is ten times higher than in the blood.

"We know that saliva reflects the composition of blood. The fact that suPAR in the blood can indicate cancer, diabetes, and other serious diseases means that our findings could open entirely new avenues for tracking various diseases in saliva," says Gustafsson.

Using saliva instead of blood samples is of great value in screening studies, as samples can be acquired with little bother to patients, who in fact can take the sample themselves at home.

Treatment with peptides

Medical care needs not only better diagnostic methods but also more effective treatment for blood poisoning. In her research Gustafsson has studied how antimicrobial peptides, AMPs, affect two different bacterial toxins, LPS and LTA.

"The results show that AMPs moderate the immune defense's reaction to LPS but strengthen the reaction to LTA. This is a truly unexpected finding, which hypothetically could mean that peptide treatment of LTA might aggravate the condition," says Gustafsson.


Story Source:

The above story is based on materials provided by Expertanswer. Note: Materials may be edited for content and length.


Cite This Page:

Expertanswer. "Protein in saliva promises new diagnostic methods." ScienceDaily. ScienceDaily, 31 May 2012. <www.sciencedaily.com/releases/2012/05/120531101901.htm>.
Expertanswer. (2012, May 31). Protein in saliva promises new diagnostic methods. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2012/05/120531101901.htm
Expertanswer. "Protein in saliva promises new diagnostic methods." ScienceDaily. www.sciencedaily.com/releases/2012/05/120531101901.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins