Featured Research

from universities, journals, and other organizations

New target, new drug in breast cancer

Date:
June 4, 2012
Source:
University of Colorado Denver
Summary:
Many breast cancers depend on hormones including estrogen or progesterone for their survival and proliferation. Eight years of lab work suggest that the androgen receptor is an additional hormonal target in many breast cancers.

Many breast cancers depend on hormones including estrogen or progesterone for their survival and proliferation. Eight years of lab work at the University of Colorado Cancer Center and elsewhere suggest that the androgen (AR) receptor is an additional hormonal target in many breast cancers. Block AR+ breast cancer's ability to access androgen and you block the cancer's ability to survive.

Related Articles


That's what the drug enzalutamide does, according to a CU Cancer Center study, presented June 2 at the American Society of Clinical Oncology (ASCO) meeting in Chicago.

"Preliminary results are promising and show that androgen receptor blockade may indeed be therapeutic," says Anthony Elias, MD, investigator at the University of Colorado Cancer Center and professor of medical oncology at the University of Colorado School of Medicine.

Elias points out that about 88 percent of estrogen-positive breast cancers, 50 percent of HER2+ breast cancers and 25 percent of triple-negative breast cancers are androgen-positive (75 percent of all breast cancers), making androgen receptors a possible first target for many cancers, or a likely second target for cancers that resist other therapies.

"Targeting androgen receptors may be especially important for patients whose cancers haven't responded to existing treatments that target estrogen or progesterone," Elias says.

The Medivation drug enzalutamide blocks the proliferative power of androgen receptors in breast cancer. In breast cancers that were both ER+ and AR+, the effect of enzalutamide against androgen was similar to the effect of the proven drug tamoxifen against estrogen.

"This is a possible, new first-line target for breast cancer care," Elias says.


Story Source:

The above story is based on materials provided by University of Colorado Denver. Note: Materials may be edited for content and length.


Cite This Page:

University of Colorado Denver. "New target, new drug in breast cancer." ScienceDaily. ScienceDaily, 4 June 2012. <www.sciencedaily.com/releases/2012/06/120604094121.htm>.
University of Colorado Denver. (2012, June 4). New target, new drug in breast cancer. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2012/06/120604094121.htm
University of Colorado Denver. "New target, new drug in breast cancer." ScienceDaily. www.sciencedaily.com/releases/2012/06/120604094121.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins