Featured Research

from universities, journals, and other organizations

New insight into placental growth and healthy pregnancy

Date:
June 10, 2012
Source:
The Babraham Institute Cambridge
Summary:
Scientists have gained a new understanding of how the growth of the placenta is regulated before birth, which has important implications for a healthy pregnancy. The research shows that the controlled release of a specific molecule, called miR-675, slows down growth of the placenta before birth.

Scientists at the Babraham Institute have gained a new understanding of how the growth of the placenta is regulated before birth, which has important implications for a healthy pregnancy. The research, published June 10 in the journal Nature Cell Biology shows that the controlled release of a specific molecule, called miR-675, slows down growth of the placenta before birth.

RNA molecules are best known as the intermediary between the cell's DNA and the making of proteins necessary for cell function. However, there are also many RNA molecules with functions other than encoding proteins. Babraham Institute scientists are involved in researching the role of these noncoding RNAs, including microRNAs (a type of short noncoding RNA molecule) which are important for regulating cell development and function.

The noncoding RNA H19 is one of the most abundant RNA molecules found in mammals but until now its function was unknown. This study, in collaboration with academics in France, the USA and Belgium, is the first to show that a microRNA called miR-675 is 'cut out' and released from the longer H19 RNA in the placenta and that this limits placental growth.

Dr Andrew Keniry from the Babraham Institute who is lead author explained, "The function of the H19 noncoding RNA has proven elusive for many years. We have shown that it appears to act as an inert molecule used to store the functional miR-675 until it is required by the cell to slow placental growth. This is a very exciting finding and reveals a new purpose for noncoding RNA. It is also intriguing that the release of miR-675 is controlled by a stress-response protein, suggesting this may be a mechanism the developing embryo can use to regulate its growth in the womb."

Professor Wolf Reik, senior author of the paper and a Group Leader at the Babraham Institute, which receives strategic funding from the Biotechnology and Biological Sciences Research Council (BBSRC) said, "It's interesting to see how the growth of the placenta can be regulated in this flexible way before birth. Perhaps there are environmental signals and influences from the mother's diet on the growth of the placenta and hence the healthy baby. It's also fascinating how an RNA that is so abundant in the cell can be a quick-release reservoir of a growth regulating small RNA, and this may be generally important for how cell growth is regulated by the environment."


Story Source:

The above story is based on materials provided by The Babraham Institute Cambridge. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew Keniry, David Oxley, Paul Monnier, Michael Kyba, Luisa Dandolo, Guillaume Smits, Wolf Reik. The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nature Cell Biology, 2012; DOI: 10.1038/ncb2521

Cite This Page:

The Babraham Institute Cambridge. "New insight into placental growth and healthy pregnancy." ScienceDaily. ScienceDaily, 10 June 2012. <www.sciencedaily.com/releases/2012/06/120610151515.htm>.
The Babraham Institute Cambridge. (2012, June 10). New insight into placental growth and healthy pregnancy. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2012/06/120610151515.htm
The Babraham Institute Cambridge. "New insight into placental growth and healthy pregnancy." ScienceDaily. www.sciencedaily.com/releases/2012/06/120610151515.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins