Featured Research

from universities, journals, and other organizations

Microbiome analysis helps understand cause of chronic sinus condition, suggests cure

Date:
June 18, 2012
Source:
American Society for Microbiology
Summary:
A study of the microbiome of the human nose provides clues to the cause of a chronic sinus condition and potential strategy for a cure.

A study of the microbiome of the human nose provides clues to the cause of a chronic sinus condition and potential strategy for a cure. Researchers from the University of California, San Francisco reported their findings recently at the 2012 General Meeting of the American Society for Microbiology.

Related Articles


Chronic rhinosinusitis (CRS) is characterized by inflammation of the nasal and paranasal sinuses lasting over 12 weeks. Patients suffering from this disease experience a variety of symptoms including congestion, fatigue, and even depression and it can lead to other conditions such as asthma, meningitis and aneurysms. Annually, it is estimated to be responsible for as many as 22 million office visits and more than 500,000 emergency department visits in the U.S. with healthcare costs reaching as high as $3.5 billion. The causes of chronic rhinosinusitis are not completely understood. This has hampered development of long-lasting, definitive treatments.

"With the fast-growing body of literature that demonstrates associations between the human microbiome composition and several diseases such as asthma and obesity, we hypothesized that a nasal microbiome exists and plays a role in CRS development," says Nabeetha Nagalingam, a researcher on the study.

In the study Nagalingam and colleagues compared the nasal microbial communities of 10 CRS patients and 10 healthy individuals. They found that patients with CRS had a depleted nasal microbiome, characterized by a significant reduction in bacterial diversity and an overgrowth of one type of bacteria, Corynebacterium spp.

"We investigated our hypothesis that C. tuberculostearicum in the setting of a depleted microbiome can induce pathophysiology consistent with sinusitis using a mouse model," says Nagalingam.

To recreate a depleted microbiome, mice were administered antibiotics for 7 days before they were infected with C. tuberculostearicum. Mice who were given the antibiotic before exposure displayed symptoms of sinusitis. Mice that were not first treated with antibiotics but exposed to the bacteria did not.

"From our human microbiome comparative profiling, we noted that lactic acid bacteria, including Lactobacillus sakei, were significantly depleted in patients with CRS and postulated that this bacterium may have a protective role against CRS development," says Nagalingam. Once again using the mouse model they showed that L. sakei inhibited the growth of C. tuberculostearicum and could prevent infection, even with a depleted nasal microbiome.

"These findings suggest that manipulation of microbial communities to restore colonization by beneficial species identified in this study may represent a novel and efficacious approach for prevention or management of CRS," says Nagalingam.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Microbiology. "Microbiome analysis helps understand cause of chronic sinus condition, suggests cure." ScienceDaily. ScienceDaily, 18 June 2012. <www.sciencedaily.com/releases/2012/06/120618161708.htm>.
American Society for Microbiology. (2012, June 18). Microbiome analysis helps understand cause of chronic sinus condition, suggests cure. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2012/06/120618161708.htm
American Society for Microbiology. "Microbiome analysis helps understand cause of chronic sinus condition, suggests cure." ScienceDaily. www.sciencedaily.com/releases/2012/06/120618161708.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins