Featured Research

from universities, journals, and other organizations

Ratio of appetite-regulating hormones marker of successful dieters

Date:
June 25, 2012
Source:
Endocrine Society
Summary:
A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study.

A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study. The results were presented June 24 at The Endocrine Society's 94th Annual Meeting in Houston.

Related Articles


With obesity rates in many countries steadily climbing, more people are turning to diets to lose weight. But, for many people, maintaining the weight loss can be extremely difficult, leading to a frustrating cycle of weight loss and gain.

"The current study shows for the first time a clinically useful marker to identify, at an early time, patients who have difficulties in maintaining their body weight," said study author Ana B. Crujeiras , Ph.D., doctor at University Hospital of Santiago de Compostela (CHUS) and Biomedical Network Research Center in Physiopathology of obesity and Nutrition (CIBERobn) in Santiago de Compestela, Spain. "This difficulty is one of the most significant obstacles for obesity therapy, and currently there are no biological markers that effectively demonstrate clinical usefulness in predicting weight-loss regain."

To address this problem, investigators analyzed the role of two hormones related to appetite regulation. Leptin is made by the cells found in fat tissue, and ghrelin is mainly manufactured by cells in the stomach. Previous research by Crujeiras and co-investigators showed that patients who later regained weight had higher leptin and lower ghrelin levels before starting a restricted-calorie diet.

In the current study, investigators found the pre-diet leptin/ghrelin ratio to be two times higher among study participants who later regained weight than among those who did not. Additionally, they identified cut-off points, which predicted more than 60 percent of patients who would later regain 10 percent or more of the weight they initially lost.

"Calculating the leptin/ghrelin ratio prior to the participation in a weight-reduction program might provide the opportunity to individualize weight-loss therapeutic programs according to patients' needs, counteracting the weight-regain rate, and, as a consequence, achieving successful management of obesity," Crujeiras said.

Among women, the leptin/ghrelin ratio identified 70 percent of participants who later regained weight. Among men, the rate was even higher at 95 percent. Women, however, were less likely than men to be incorrectly identified as future weight gainers.

Eighty-eight overweight or obese patients, with a body mass index greater than 25, enrolled in the eight-week study. They were 44 percent female, their average age was 35 years, and all were white.

After an initial fast, participants' blood levels of leptin and ghrelin were measured. They then followed a reduced calorie diet for eight weeks. At the six-month follow-up, 40 dieters had regained the weight they had lost, while the remaining 48 had not. The Biomedical Network Research Centre in Physiopathology of obesity and Nutrition (CIBERobn), Institute of Health Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness; Galician Research, Development and Technological Innovation plan (INCITE), Galician Ministry for Innovation and Industry; and Special Research about Nutrition, Obesity and Health, University of Navarra funded the study.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Ratio of appetite-regulating hormones marker of successful dieters." ScienceDaily. ScienceDaily, 25 June 2012. <www.sciencedaily.com/releases/2012/06/120625125046.htm>.
Endocrine Society. (2012, June 25). Ratio of appetite-regulating hormones marker of successful dieters. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2012/06/120625125046.htm
Endocrine Society. "Ratio of appetite-regulating hormones marker of successful dieters." ScienceDaily. www.sciencedaily.com/releases/2012/06/120625125046.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins