Featured Research

from universities, journals, and other organizations

Fetal growth restriction affected by formation of maternal gene

Date:
June 26, 2012
Source:
Allen Press Publishing Services
Summary:
A Japanese study has found that maternal rather than fetal factors are associated with fetal growth restriction. A comparison of maternal and fetal angiotensin-converting enzyme genotypes with the size of babies at birth found evidence of this connection. This finding lends support to the hypothesis that reduced placental blood flow leads to fetal growth restriction.

A Japanese study has found that maternal rather than fetal factors are associated with fetal growth restriction. A comparison of maternal and fetal angiotensin-converting enzyme genotypes with the size of babies at birth found evidence of this connection. This finding lends support to the hypothesis that reduced placental blood flow leads to fetal growth restriction.

The current issue of the journal Pediatric and Developmental Pathology reports results of a study of 470 pairs of mothers and babies in Japan. Mothers and babies were genotyped using maternal and cord blood, and the weight, length, head circumference, and incidence of small-for-gestational age status were recorded for full-term newborn infants.

The renin-angiotensin system is a hormone system that regulates blood pressure and fluid balance in the body. The maternal renin-angiotensin system affects the regulation of uteroplacental blood flow. A disorder in the maternal system may contribute to reduced placental blood flow, preeclampsia, and intrauterine growth restriction.

This study focused on both maternal and fetal insertion or deletion polymorphism of the angiotensin-converting enzyme gene. Pairing of either insertion/insertion, insertion/deletion, or deletion/deletion gene alleles was identified. In adults, this insertion or deletion polymorphism is considered a marker of renin-angiotensin system function, and has been associated with cardiovascular disorders. Its role in incidents related to pregnancy has not been as clearly defined.

In this study, researchers found that the incidence of small-for-gestational age in babies whose mothers had one or two deletion alleles was greater than that in babies whose mothers had two insertion alleles. No significant differences between these groups were found when analyzing the infants' alleles.

This investigation provides evidence that the maternal renin-angiotensin system, rather than the fetal system, has a greater effect on fetal growth. Fetal growth may be restricted by reduced blood flow for a fetus whose mother has a D allele.


Story Source:

The above story is based on materials provided by Allen Press Publishing Services. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eiki Nakamura, Toshio Okamoto, Ken Nagaya, Tokitsugi Hayashi. Maternal Deletion Allele of Angiotensin-Converting Enzyme Gene Is Associated with Fetal Growth Restriction. Pediatric and Developmental Pathology, 2012; 15 (2): 114 DOI: 10.2350/11-09-1092-OA.1

Cite This Page:

Allen Press Publishing Services. "Fetal growth restriction affected by formation of maternal gene." ScienceDaily. ScienceDaily, 26 June 2012. <www.sciencedaily.com/releases/2012/06/120626113928.htm>.
Allen Press Publishing Services. (2012, June 26). Fetal growth restriction affected by formation of maternal gene. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/06/120626113928.htm
Allen Press Publishing Services. "Fetal growth restriction affected by formation of maternal gene." ScienceDaily. www.sciencedaily.com/releases/2012/06/120626113928.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins