Featured Research

from universities, journals, and other organizations

Ultrasound triggers bone cell mobility

Date:
July 17, 2012
Source:
Stony Brook Medicine
Summary:
Scientists have demonstrated that the use of medium-intensity focused ultrasound on osteoblasts, known as bone-forming cells, stimulates the mobility of the cells and triggers calcium release, a process that promotes growth. The technique could provide a foundation for a method to develop non-pharmacologic treatments of osteoporosis, fractures, and other conditions involving bone loss.

Dr. Yi-Xian Qin, and Department of Biomedical Engineering graduate student, Jordan Rustad, look at evidence of changes in bone-forming cells as a result of exposure to ultrasound.
Credit: Image courtesy of Stony Brook Medicine

Research led by Yi-Xian Qin, PhD, Professor, Department of Biomedical Engineering, and Director of the Orthopaedic Bioengineering Research Laboratory at Stony Brook University, demonstrated that the use of medium-intensity focused ultrasound on osteoblasts, known as bone-forming cells, stimulates the mobility of the cells and triggers calcium release, a process that promotes growth. The technique could provide a foundation for a method to develop non-pharmacologic treatments of osteoporosis, fractures, and other conditions involving bone loss.

Related Articles


Musculoskeletal tissues, like bone and muscle, have a robust state of dynamic equilibrium in response to mechanical loading and respond to significant stimuli, such as exercise. Dr. Qin and Stony Brook colleagues Drs. Shu Zhang and Jiqi Cheng are investigating how osteoblasts (a bone-forming cell) respond to mechanical signals, such as ultrasound. In laboratory models of murine cells, the research team created a unique method to apply an ultrasound form called acoustic radiation force (ARF) for only one minute on a single osteoblastic cell and groups of cells. They consistently found that ARF through focused ultrasound beam induced cellular cytoskeletal rearrangement, the motility and mobility of the cells, and accelerated intracellular calcium transportations and concentrations.

Dr. Qin's previous findings with ultrasound include the creation of an ultrasound bone scanning device that is more advanced than existing ultrasound technology and assesses bone parameters beyond mineral density. The device is being developed as a diagnostic tool to predict early bone loss. Dr. Qin and his research team is investigating ways to combine this potential diagnostic tool with the ARF technology in the laboratory to identify bone loss and fracture within a bone region, then provide treatment via ARF to promote growth and healing.

The research projects are supported in part by the National Institutes of Health, and the National Space Biomedical Research Institute through a NASA Cooperative Agreement.


Story Source:

The above story is based on materials provided by Stony Brook Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shu Zhang, Jiqi Cheng, Yi-Xian Qin. Mechanobiological Modulation of Cytoskeleton and Calcium Influx in Osteoblastic Cells by Short-Term Focused Acoustic Radiation Force. PLoS ONE, 2012; 7 (6): e38343 DOI: 10.1371/journal.pone.0038343

Cite This Page:

Stony Brook Medicine. "Ultrasound triggers bone cell mobility." ScienceDaily. ScienceDaily, 17 July 2012. <www.sciencedaily.com/releases/2012/07/120717182959.htm>.
Stony Brook Medicine. (2012, July 17). Ultrasound triggers bone cell mobility. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2012/07/120717182959.htm
Stony Brook Medicine. "Ultrasound triggers bone cell mobility." ScienceDaily. www.sciencedaily.com/releases/2012/07/120717182959.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins