Featured Research

from universities, journals, and other organizations

Parkinson's: Newly discovered antibody could facilitate early diagnosis

Date:
July 20, 2012
Source:
Medical University of Vienna
Summary:
Conditions such as Parkinson’s disease are a result of pathogenic changes to proteins. In the neurodegenerative condition of Parkinson’s disease, which is currently incurable, the alpha-synuclein protein changes and becomes pathological. Until now, there have not been any antibodies that could help to demonstrate the change in alpha-synuclein associated with the disease. Medical researchers have now discovered a new antibody that actually possesses this ability.

Conditions such as Parkinson's disease are a result of pathogenic changes to proteins. In the neurodegenerative condition of Parkinson's disease, which is currently incurable, the alpha-synuclein protein changes and becomes pathological. Until now, there have not been any antibodies that could help to demonstrate the change in alpha-synuclein associated with the disease. An international team of experts led by Gabor G. Kovacs from the Clinical Institute of Neurology at the MedUni Vienna has now discovered a new antibody that actually possesses this ability.

Related Articles


"It opens up new possibilities for the development of a diagnostic test for Parkinsonism," says Kovacs, highlighting the importance of this discovery. "This new antibody will enable us to find the pathological conformation in bodily fluids such as blood or CSF." A clinical study involving around 200 patients is already underway, and the first definitive results are expected at the end of 2012. The tests being carried out in collaboration with the University Department of Neurology, led by Walter Pirker, are designed to determine the extent to which the new antibody can be used as an early diagnostic tool in order to understand the condition better and be able to treat it more effectively.

A step towards a blood test for Parkinson's With Parkinsonism, the diseased form of alpha-synuclein, which has the same primary structure as the healthy form, undergoes an "abnormal fold." Says Kovacs: "Until now, however, it was not possible to distinguish between the two." The previous immunodiagnostic techniques only allowed the general presence of alpha-synuclein to be confirmed. The new, monoclonal antibody, however, which the researchers at the MedUni Vienna have developed in collaboration with the German biotech firm Roboscreen, is now able to detect a strategic part of the protein responsible for the structural changes. The results of the study have now been published in the journal Acta Neuropathologica.

Says Kovacs: "It is still not possible to say whether or not we will be able to diagnose Parkinson's from a blood test, but this discovery certainly represents a major step in that direction." Theoretically, it should be possible to diagnose Parkinson's disease five to eight years before it develops.

In Austria, there are between 15,000 and 16,000 people living with Parkinson's syndrome. Its frequency increases with age. As society becomes older, Parkinson's disease, a degenerative condition of the brain, will become an increasingly widespread problem.


Story Source:

The above story is based on materials provided by Medical University of Vienna. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gabor G. Kovacs, Uta Wagner, Benoit Dumont, Maria Pikkarainen, Awad A. Osman, Nathalie Streichenberger, Irene Leisser, Jιrιmy Verchθre, Thierry Baron, Irina Alafuzoff, Herbert Budka, Armand Perret-Liaudet, Ingolf Lachmann. An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology. Acta Neuropathologica, 2012; 124 (1): 37 DOI: 10.1007/s00401-012-0964-x

Cite This Page:

Medical University of Vienna. "Parkinson's: Newly discovered antibody could facilitate early diagnosis." ScienceDaily. ScienceDaily, 20 July 2012. <www.sciencedaily.com/releases/2012/07/120720083034.htm>.
Medical University of Vienna. (2012, July 20). Parkinson's: Newly discovered antibody could facilitate early diagnosis. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2012/07/120720083034.htm
Medical University of Vienna. "Parkinson's: Newly discovered antibody could facilitate early diagnosis." ScienceDaily. www.sciencedaily.com/releases/2012/07/120720083034.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins