Featured Research

from universities, journals, and other organizations

New anesthesia drugs developed to be 'fast, clean, and soft'

Date:
July 31, 2012
Source:
International Anesthesia Research Society (IARS)
Summary:
Researchers are using sophisticated and powerful new tools to develop and evaluate new anesthetic agents with important advantages over current drugs, according to a several new articles.

Researchers are using sophisticated and powerful new tools to develop and evaluate new anesthetic agents with important advantages over current drugs, according to a set of papers in the August issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

The new techniques open the way to rapid development of better, safer anesthetics with real benefits for patient care, according to an accompanying editorial by Dr Ken B. Johnson of University of Utah, Salt Lake City.

Advanced Techniques Used to Design Better Anesthetics The August A&A reports on the development and initial evaluation of two new anesthesia agents. Separate research groups are using a combination of older and newer techniques -- including molecular-level techniques and computer stimulations -- for "fast, clean, and soft" drug development. Using these advanced techniques enables researchers to achieve "faster" development of anesthetics that are "softer," with more predictable effects and metabolism; and "cleaner," without unwanted side effects.

Researchers at Massachusetts General Hospital, Boston, report on the development of an improved version of etomidate -- a sedative commonly used to induce general anesthesia in patients who are elderly, critically ill, or in unstable condition. Unfortunately, etomidate also causes suppression of adrenocortical function. This can interfere with production of steroid substances that play an important role in immunity and other key functions.

The researchers identified the specific feature of the etomidate molecule -- a "pyrrole ring" -- responsible for blocking adrenocortical function. Armed with this knowledge, they modified the pyrrole ring to created new versions of etomidate. They report initial pharmacological studies of a new "MOC-carboetomidate" that combines the potent sedative activity with rapid metabolism and clearance from the brain. The new drug promotes hemodynamic stability, without suppressing adrenocortical function.

A group of researchers from PAION UK, Ltd, and Johns Hopkins University School of Medicine report on the development a new benzodiazepine-type sedative drug called remimazolam. Again, molecular-level techniques were used to create a new benzodiazepine drug with more favorable properties: "fast onset, a short, predictable duration of sedative action, and a more rapid recovery profile than currently available drugs."

The researchers report the use of computerized models and simulation techniques to explore the basic properties of the remimazolam. The results suggested very rapid sedation, reaching peak effect within three minutes, which should allow more accurate tailoring of the final dose.

The new techniques may facilitate the evaluation of remimazolam from initial human studies to final clinical trials. Dr Johnson also notes that some of the simulation techniques used in the studies provide useful and detailed information for anesthesiologists to use in comparing the effects of different anesthetics.

The new reports provide a timely illustration of the way anesthesiology researchers are using advanced techniques to develop and introduce new agents that will help to make anesthesia more effective and safer for patients. Dr Johnson concludes, "Through their efforts, remimazolam and the MOC etomidate analogs will likely bring interesting advances to our specialty in the coming years!"

Journal: http://www.anesthesia-analgesia.org/


Story Source:

The above story is based on materials provided by International Anesthesia Research Society (IARS). Note: Materials may be edited for content and length.


Cite This Page:

International Anesthesia Research Society (IARS). "New anesthesia drugs developed to be 'fast, clean, and soft'." ScienceDaily. ScienceDaily, 31 July 2012. <www.sciencedaily.com/releases/2012/07/120731123251.htm>.
International Anesthesia Research Society (IARS). (2012, July 31). New anesthesia drugs developed to be 'fast, clean, and soft'. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2012/07/120731123251.htm
International Anesthesia Research Society (IARS). "New anesthesia drugs developed to be 'fast, clean, and soft'." ScienceDaily. www.sciencedaily.com/releases/2012/07/120731123251.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins