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Gene 'switch' may explain DiGeorge syndrome severity

Date:
August 23, 2012
Source:
Walter and Eliza Hall Institute
Summary:
The discovery of a 'switch' that modifies a gene known to be essential for normal heart development could explain variations in the severity of birth defects in children with DiGeorge syndrome.

Dr Anne Voss (right) and Dr Tim Thomas have found a 'switch' that modifies a gene essential for normal heart development.
Credit: Image courtesy of Walter and Eliza Hall Institute

The discovery of a 'switch' that modifies a gene known to be essential for normal heart development could explain variations in the severity of birth defects in children with DiGeorge syndrome.

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Researchers from the Walter and Eliza Hall Institute made the discovery while investigating fetal development in an animal model of DiGeorge syndrome. DiGeorge syndrome affects approximately one in 4000 babies.

Dr Anne Voss and Dr Tim Thomas led the study, with colleagues from the institute's Development and Cancer division, published August 23 in the journal Developmental Cell.

Dr Voss said babies with DiGeorge syndrome have a characteristic DNA mutation on chromosome 22 (22q11 -- chromosome 22, long arm, band 11), but exhibit a range of mild to severe birth defects, including heart and aorta defects.

"The variation in symptoms is so prominent that even identical twins, with the exact same DNA sequence, can have remarkably different conditions," she said. "We hypothesised that environmental factors were probably responsible for the variation, via changes to the way in which genetic material is packaged in the chromatin," Dr Voss said.

Chromatin is the genetic material that comprises DNA and associated proteins packaged together in the cell nucleus. Chemical marks that sit on the chromatin modify it to instruct when and where to switch genes on or off, making a profound difference to normal development and cellular processes.

The research team found a protein called MOZ, the 'switch' which is involved in chromatin modification, was a key to explaining the range of defects seen in an animal model of DiGeorge syndrome. "MOZ is what we call an chromatin modifier, which means it is responsible for making marks on the chromatin that tell genes to switch on or off," Dr Voss said.

"In this study, we showed that MOZ regulates the major gene, called Tbx1, in the 22q11 deletion. Tbx1 is responsible for heart and aortic arch development. In mouse models that have no Moz gene, Tbx1 does not work properly, and the embryos have similar heart and aorta defects to those seen in children with DiGeorge syndrome. We showed that MOZ is crucial for normal activity of Tbx1, and the level of MOZ activity may contribute to determining how severe the defects are in children with DiGeorge syndrome," Dr Voss said.

Dr Voss said the study also showed that the severity of birth defects in DiGeorge syndrome could be compounded by the mother's diet, particularly if the MOZ switch is not working properly. The research team showed that reduced MOZ activity could conspire with excess retinoic acid (a type of vitamin A) to markedly increase the frequency and severity of DiGeorge syndrome.

"In our mouse model, we saw that retinoic acid exacerbated the defects seen in mice with mutations in the Moz gene. In fact, in mice that had one normal copy of MOZ and one mutated copy, the offspring look completely normal, but if the mother's diet was high in vitamin A, the offspring developed a DiGeorge-like syndrome. This suggests that MOZ, when coupled with a diet high in vitamin A (retinoic acid), may play a role in the development of DiGeorge syndrome in some cases.

"This interaction between the chromatin modifier MOZ, the Tbx1 gene, and retinoic acid in the diet gives a rare insight of how the environment and genetic mutations can interact at the chromatin level to cause birth defects."

The work is supported by the National Health and Medical Research Council of Australia, British Heart Foundation, Australian Stem Cell Centre and the Victorian Government.


Story Source:

The above story is based on materials provided by Walter and Eliza Hall Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. AnneK. Voss, HannahK. Vanyai, Caitlin Collin, MathewP. Dixon, TamaraS. McLennan, BilalN. Sheikh, Peter Scambler, Tim Thomas. MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome. Developmental Cell, 2012; DOI: 10.1016/j.devcel.2012.07.010

Cite This Page:

Walter and Eliza Hall Institute. "Gene 'switch' may explain DiGeorge syndrome severity." ScienceDaily. ScienceDaily, 23 August 2012. <www.sciencedaily.com/releases/2012/08/120823143101.htm>.
Walter and Eliza Hall Institute. (2012, August 23). Gene 'switch' may explain DiGeorge syndrome severity. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2012/08/120823143101.htm
Walter and Eliza Hall Institute. "Gene 'switch' may explain DiGeorge syndrome severity." ScienceDaily. www.sciencedaily.com/releases/2012/08/120823143101.htm (accessed February 28, 2015).

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