Featured Research

from universities, journals, and other organizations

Novel blood test predicts sudden death risk patients who would benefit from ICDs

Date:
August 26, 2012
Source:
European Society of Cardiology (ESC)
Summary:
A novel blood test that predicts sudden death risk in heart failure patients is set to help physicians decide which patients would benefit from implantable cardioverter defibrillators (ICDs). Approximately 5 million patients in the US have heart failure, a condition where the heart is unable to pump blood adequately, and nearly 550,000 people are diagnosed annually. Heart failure is the single most common cause of admission to hospitals in the US.

Figure 1 shows the distributions of the C type SCN5A variant (VC) in controls, patients with heart failure (HF) and no sudden death (i.e. no ICD shocks), and patients with HF and a sudden death episode (i.e. with ICD shocks). The separation of the distributions of patients with and without a sudden death episode allows for a discriminatory test. Figure 2 is a receiver operating characteristic (ROC) curve which shows that the discriminatory power of the C or D type variants of SCN5A as measured by the area under the curve are equivalent and much higher than an ejection fraction of less than or equal to 20%.
Credit: Image courtesy of ESC

A novel blood test that predicts sudden death risk in heart failure patients is set to help physicians decide which patients would benefit from implantable cardioverter defibrillators (ICDs). The findings were presented at the ESC Congress 2012 August 26 by Professor Samuel Dudley from Chicago, IL, US.

Approximately 5 million patients in the US have heart failure, a condition where the heart is unable to pump blood adequately, and nearly 550,000 people are diagnosed annually. Heart failure is the single most common cause of admission to hospitals in the US.

ICDs, which are devices similar to pacemakers, can monitor and treat abnormal heartbeats and are surgically implanted in patients with severe heart failure to prevent sudden death. "The problem is that more than half of the patients who get them don't need them, and nearly half of the patients who would benefit don't get one," said Professor Dudley, who is professor of medicine and physiology at the University of Illinois at Chicago College of Medicine and principle investigator of the study.

The clinical trial presented at the ESC Congress 2012 showed that a blood test can predict which patients will need a defibrillator in the next year. The test, called PulsePredic, discriminates with high predictive power who will or will not need an ICD to prevent abnormal heartbeats and subsequent sudden death.

The simple laboratory test identifies changes in the gene message (mRNA) for the SCN5A gene, which is known to be involved in sudden death. The increase in the changed gene message was able to predict who would have a sudden death episode requiring defibrillation. "The test predicts whether you will have sudden death from heart failure and whether you will need a defibrillator in the next year," said Professor Dudley.

The SCN5A gene encodes for proteins, called voltage-gated sodium channels, responsible for generating the main current for electrical activity in the heart. Alterations in the sodium current, either up or down, lead to arrhythmias.

Professor Dudley and his team evaluated the new blood test in 180 adult patients, including 135 patients with heart failure and 45 patients without heart failure as controls. Patients with congenital heart disease, infections, and inflammatory conditions were excluded.

The SCN5A gene was measured in heart muscle cells and white blood cells. The changes in the gene message were able to predict who would have a sudden death episode requiring defibrillation. Heart failure patients who had abnormal heartbeats that would normally cause sudden death had significantly higher levels of these gene variants compared to patients who did not have abnormal heartbeats. The amount of variants in the blood had excellent predictive power to determine arrhythmic risk, suggesting that a blood test for sudden death risk and the need for an ICD is possible.

"This is the first test of its kind," said Professor Dudley. "It is amazing stuff, with promise to change dramatically the way we direct treatments to patients at risk for sudden death."

The next steps in the development of the test will be to carry out a larger trial and work with regulatory agencies to receive approval for clinical use.

Contributors: Samuel Dudley, Ge Gao, Vikram Brahmanandam, Mihai Raicu, Srinivasan Kasturirangan, Lianzhi Gu, Alan Schwartz and Smita Negi.


Story Source:

The above story is based on materials provided by European Society of Cardiology (ESC). Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology (ESC). "Novel blood test predicts sudden death risk patients who would benefit from ICDs." ScienceDaily. ScienceDaily, 26 August 2012. <www.sciencedaily.com/releases/2012/08/120826143344.htm>.
European Society of Cardiology (ESC). (2012, August 26). Novel blood test predicts sudden death risk patients who would benefit from ICDs. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2012/08/120826143344.htm
European Society of Cardiology (ESC). "Novel blood test predicts sudden death risk patients who would benefit from ICDs." ScienceDaily. www.sciencedaily.com/releases/2012/08/120826143344.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins