Featured Research

from universities, journals, and other organizations

A promising start for new anticancer drug

Date:
September 3, 2012
Source:
Asociación RUVID
Summary:
Spanish researchers have developed on a nanometric scale a new drug that combines photothermia and chemotherapy to help fight cancer.

Pablo Botella.
Credit: Image courtesy of Asociación RUVID

Spanish researchers have developed on a nanometric scale a new drug that combines photothermia and chemotherapy to help fight cancer.

Related Articles


Until now, researchers have applied this new drug on human glioma cell cultures in the laboratory. The results are particularly interesting for the treatment of skin cancer (melanoma) and solid tumors of the nervous system such as gliomas. The work was coordinated by Professor Eduardo Fernández Jover (Miguel Hernández University of Elche) and Pablo Botella, researcher at the Institute of Chemical Technology of Valencia.

The new drug comprises hybrid particles containing clusters of gold nanoparticles protected by a covering of porous silica which incorporates molecules of an antitumor drug (camptothecin). The gold nanoclusters have photothermal activity, absorbing the light generated by a biomedical laser. Pablo Botella explains that while organic tissues are virtually transparent to this radiation, its absorption by the gold nanoclusters causes a large local temperature increase. "When this occurs within a cancer cell, the high internal stress leads to its destruction."

The accumulation of these nanoparticles in cancer cells is greatly favoured by the increase of vascular permeability that occurs at a tumor level. Furthermore the release of chemotherapeutic agents transported inside the porous cover of the particles, eliminates those malignant cells that have not been reached by the laser. "This ensures much greater effectiveness than traditional therapy, and the absence of side effects from the antitumor drug in other tissues," says Professor Eduardo Fernández.

"The study has completed its initial phase conducted on cell cultures and, currently, there are plans to develop the next preclinical stage on animal models of skin cancer and gliomas. However, it is still early days to start on humans," the researchers conclude.


Story Source:

The above story is based on materials provided by Asociación RUVID. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pablo Botella, Ílida Ortega, Manuel Quesada, Roque F. Madrigal, Carlos Muniesa, Antonio Fimia, Eduardo Fernández, Avelino Corma. Multifunctional hybrid materials for combined photo and chemotherapy of cancer. Dalton Transactions, 2012; 41 (31): 9286 DOI: 10.1039/C2DT30381G

Cite This Page:

Asociación RUVID. "A promising start for new anticancer drug." ScienceDaily. ScienceDaily, 3 September 2012. <www.sciencedaily.com/releases/2012/09/120903142953.htm>.
Asociación RUVID. (2012, September 3). A promising start for new anticancer drug. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2012/09/120903142953.htm
Asociación RUVID. "A promising start for new anticancer drug." ScienceDaily. www.sciencedaily.com/releases/2012/09/120903142953.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) — After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) — Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) — A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins