Featured Research

from universities, journals, and other organizations

A promising start for new anticancer drug

Date:
September 3, 2012
Source:
Asociación RUVID
Summary:
Spanish researchers have developed on a nanometric scale a new drug that combines photothermia and chemotherapy to help fight cancer.

Pablo Botella.
Credit: Image courtesy of Asociación RUVID

Spanish researchers have developed on a nanometric scale a new drug that combines photothermia and chemotherapy to help fight cancer.

Until now, researchers have applied this new drug on human glioma cell cultures in the laboratory. The results are particularly interesting for the treatment of skin cancer (melanoma) and solid tumors of the nervous system such as gliomas. The work was coordinated by Professor Eduardo Fernández Jover (Miguel Hernández University of Elche) and Pablo Botella, researcher at the Institute of Chemical Technology of Valencia.

The new drug comprises hybrid particles containing clusters of gold nanoparticles protected by a covering of porous silica which incorporates molecules of an antitumor drug (camptothecin). The gold nanoclusters have photothermal activity, absorbing the light generated by a biomedical laser. Pablo Botella explains that while organic tissues are virtually transparent to this radiation, its absorption by the gold nanoclusters causes a large local temperature increase. "When this occurs within a cancer cell, the high internal stress leads to its destruction."

The accumulation of these nanoparticles in cancer cells is greatly favoured by the increase of vascular permeability that occurs at a tumor level. Furthermore the release of chemotherapeutic agents transported inside the porous cover of the particles, eliminates those malignant cells that have not been reached by the laser. "This ensures much greater effectiveness than traditional therapy, and the absence of side effects from the antitumor drug in other tissues," says Professor Eduardo Fernández.

"The study has completed its initial phase conducted on cell cultures and, currently, there are plans to develop the next preclinical stage on animal models of skin cancer and gliomas. However, it is still early days to start on humans," the researchers conclude.


Story Source:

The above story is based on materials provided by Asociación RUVID. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pablo Botella, Ílida Ortega, Manuel Quesada, Roque F. Madrigal, Carlos Muniesa, Antonio Fimia, Eduardo Fernández, Avelino Corma. Multifunctional hybrid materials for combined photo and chemotherapy of cancer. Dalton Transactions, 2012; 41 (31): 9286 DOI: 10.1039/C2DT30381G

Cite This Page:

Asociación RUVID. "A promising start for new anticancer drug." ScienceDaily. ScienceDaily, 3 September 2012. <www.sciencedaily.com/releases/2012/09/120903142953.htm>.
Asociación RUVID. (2012, September 3). A promising start for new anticancer drug. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/09/120903142953.htm
Asociación RUVID. "A promising start for new anticancer drug." ScienceDaily. www.sciencedaily.com/releases/2012/09/120903142953.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) — Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins