Featured Research

from universities, journals, and other organizations

TB outbreaks could be 'solved' by DNA tracking, scientists say

Date:
September 4, 2012
Source:
Society for General Microbiology
Summary:
Reconstructing the spread of killer diseases such as tuberculosis (TB) from person to person using DNA sequencing quickly identifies the origin and movement of pathogens. This approach is directly informing public health strategies to control infectious disease outbreaks, scientists say.

Reconstructing the spread of killer diseases such as tuberculosis (TB) from person to person using DNA sequencing quickly identifies the origin and movement of pathogens. This approach is directly informing public health strategies to control infectious disease outbreaks, says a scientist speaking at the Society for General Microbiology's Autumn Conference at the University of Warwick.

Related Articles


A team from the British Columbia Centre for Disease Control in Vancouver, Canada used whole-genome sequencing to analyse the bacterial DNA in samples from 36 of 41 infected individuals in a TB outbreak. They were able to track the pathogen's movements through the community in British Columbia, including where it started and who infected whom. From this they could identify key persons, places, and behaviours that contributed to the spread of disease. They showed how the social structure of a community contributed to the rapid spread of TB and that a rise in crack cocaine use in the area may have triggered the outbreak.

Earlier epidemiological tools analysed some -- but not all -- of the DNA in infected samples. This gave too little information to accurately reconstruct an outbreak and scientists could only make informed guesses at how a pathogen spread through a population. Lead researcher Dr Jennifer Gardy, speaking at the conference said, "'Solving' an outbreak -- identifying the source of the disease and the underlying patterns of transmission -- is the proverbial holy grail of epidemiology. Using whole-genome sequencing we are now able to act like field naturalists and observe how pathogens behave out in the wild. We can see where outbreaks start and how they spread. This level of insight has never been seen before and it promises to change the way we do public heath outbreak investigations."

The group is currently applying the same reconstruction technique to a different TB outbreak in a different social setting. "We are discovering how important location-based transmission is, and that identifying and screening individuals who visited these locations are integral to outbreak management," explained Dr Gardy. Other research groups are applying this genome-based approach for outbreak reconstruction to other micro-organisms. "We hope to build a 'pathogen knowledge base' that describes how different communicable diseases spread in different social and environmental settings. From this we will be able to identify commonalities that can be targeted in global public health interventions."

The work is directly informing public health policy and practice, said Dr Gardy. "As frontline public health practitioners we are using whole-genome sequencing to answer pressing questions. We are able to take our research findings and translate them into clinical action in the short term. With better control and prevention programmes, we can ultimately reduce the burden of certain infectious diseases," she said.


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "TB outbreaks could be 'solved' by DNA tracking, scientists say." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120903221044.htm>.
Society for General Microbiology. (2012, September 4). TB outbreaks could be 'solved' by DNA tracking, scientists say. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2012/09/120903221044.htm
Society for General Microbiology. "TB outbreaks could be 'solved' by DNA tracking, scientists say." ScienceDaily. www.sciencedaily.com/releases/2012/09/120903221044.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins