Featured Research

from universities, journals, and other organizations

TB outbreaks could be 'solved' by DNA tracking, scientists say

Date:
September 4, 2012
Source:
Society for General Microbiology
Summary:
Reconstructing the spread of killer diseases such as tuberculosis (TB) from person to person using DNA sequencing quickly identifies the origin and movement of pathogens. This approach is directly informing public health strategies to control infectious disease outbreaks, scientists say.

Reconstructing the spread of killer diseases such as tuberculosis (TB) from person to person using DNA sequencing quickly identifies the origin and movement of pathogens. This approach is directly informing public health strategies to control infectious disease outbreaks, says a scientist speaking at the Society for General Microbiology's Autumn Conference at the University of Warwick.

A team from the British Columbia Centre for Disease Control in Vancouver, Canada used whole-genome sequencing to analyse the bacterial DNA in samples from 36 of 41 infected individuals in a TB outbreak. They were able to track the pathogen's movements through the community in British Columbia, including where it started and who infected whom. From this they could identify key persons, places, and behaviours that contributed to the spread of disease. They showed how the social structure of a community contributed to the rapid spread of TB and that a rise in crack cocaine use in the area may have triggered the outbreak.

Earlier epidemiological tools analysed some -- but not all -- of the DNA in infected samples. This gave too little information to accurately reconstruct an outbreak and scientists could only make informed guesses at how a pathogen spread through a population. Lead researcher Dr Jennifer Gardy, speaking at the conference said, "'Solving' an outbreak -- identifying the source of the disease and the underlying patterns of transmission -- is the proverbial holy grail of epidemiology. Using whole-genome sequencing we are now able to act like field naturalists and observe how pathogens behave out in the wild. We can see where outbreaks start and how they spread. This level of insight has never been seen before and it promises to change the way we do public heath outbreak investigations."

The group is currently applying the same reconstruction technique to a different TB outbreak in a different social setting. "We are discovering how important location-based transmission is, and that identifying and screening individuals who visited these locations are integral to outbreak management," explained Dr Gardy. Other research groups are applying this genome-based approach for outbreak reconstruction to other micro-organisms. "We hope to build a 'pathogen knowledge base' that describes how different communicable diseases spread in different social and environmental settings. From this we will be able to identify commonalities that can be targeted in global public health interventions."

The work is directly informing public health policy and practice, said Dr Gardy. "As frontline public health practitioners we are using whole-genome sequencing to answer pressing questions. We are able to take our research findings and translate them into clinical action in the short term. With better control and prevention programmes, we can ultimately reduce the burden of certain infectious diseases," she said.


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "TB outbreaks could be 'solved' by DNA tracking, scientists say." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120903221044.htm>.
Society for General Microbiology. (2012, September 4). TB outbreaks could be 'solved' by DNA tracking, scientists say. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/09/120903221044.htm
Society for General Microbiology. "TB outbreaks could be 'solved' by DNA tracking, scientists say." ScienceDaily. www.sciencedaily.com/releases/2012/09/120903221044.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins