Featured Research

from universities, journals, and other organizations

Stiffening of aortic wall linked with increased risk of high blood pressure

Date:
September 4, 2012
Source:
JAMA and Archives Journals
Summary:
An analysis of the relationship between several vascular function measures and blood pressure levels finds that certain measures including higher aortic stiffness were associated with a higher risk of new hypertension; however, initial blood pressure was not independently associated with risk of progressive aortic stiffening, suggesting that vascular stiffness may be a precursor rather than the result of hypertension.

An analysis of the relationship between several vascular function measures and blood pressure levels finds that certain measures including higher aortic stiffness were associated with a higher risk of new hypertension; however, initial blood pressure was not independently associated with risk of progressive aortic stiffening, suggesting that vascular stiffness may be a precursor rather than the result of hypertension, according to a study in the September 5 issue of JAMA.

"Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. A compliant aorta provides an important buffer for each ventricular contraction that maintains pulse pressure at low levels. Stiffening of the aortic wall and improper matching between aortic diameter and flow are associated with unfavorable alterations in pulsatile hemodynamics, including an increase in forward arterial pressure wave amplitude, which increases pulse pressure," according to background information in the article.

"The association between vascular stiffening and blood pressure is particularly interesting because the functional relationship is likely bidirectional. Elevated blood pressure may cause vascular damage and accelerated conduit artery stiffening. Conversely, aortic stiffening increases pressure pulsatility and therefore affects systolic blood pressure. However, temporal relationships between vascular stiffness and blood pressure remain incompletely elucidated. In particular, whether vascular stiffness antedates hypertension or vice versa is unclear."

Bernhard M. Kaess, M.D., of the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass., and colleagues the examined temporal relationship between vascular stiffening and blood pressure by evaluating vascular stiffness, central hemodynamics, peripheral blood pressure, and incident hypertension. The investigation was based on the 2 latest examination cycles (cycle 7: 1998-2001; cycle 8: 2005-2008 [last visit: January 25, 2008]) of the Framingham Offspring study (recruited: 1971-1975). Temporal relationships among blood pressure and 3 measures of vascular stiffness and pressure pulsatility derived from arterial tonometry (carotid-femoral pulse wave velocity [CFPWV], forward wave amplitude [FWA], and augmentation index) were examined over a 7-year period in 1,759 participants (average age, 60 years). The primary outcome measures were blood pressure and incident hypertension during examination cycle 8. The secondary outcomes were CFPVW, FWA, and augmentation index during examination cycle 8.

The researchers found that aortic stiffness, central FWA, and wave reflection were jointly associated with future systolic blood pressure, pulse pressure, and incident hypertension. Initial blood pressure traits were associated with future FWA and augmentation index but not with aortic stiffness assessed by CFPWV.

Brachial artery measures of microvascular resistance and endothelial function were jointly associated with incident hypertension after considering blood pressure and tonometry variables.

"Our data suggest that aortic stiffness, central pressure pulsatility, peripheral wave reflection, large artery endothelial function, and microvascular function jointly antedate and potentially contribute to the development of clinical hypertension. Arterial stiffness and function may therefore be important potential targets for interventions aimed at preventing incident hypertension," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kaess BM, Rong J, Larson MG, et al. Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension. JAMA, 2012; 308 (9): 875-881 DOI: 10.1001/2012.jama.10503

Cite This Page:

JAMA and Archives Journals. "Stiffening of aortic wall linked with increased risk of high blood pressure." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904162531.htm>.
JAMA and Archives Journals. (2012, September 4). Stiffening of aortic wall linked with increased risk of high blood pressure. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2012/09/120904162531.htm
JAMA and Archives Journals. "Stiffening of aortic wall linked with increased risk of high blood pressure." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904162531.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins