Featured Research

from universities, journals, and other organizations

Thickening of the heart's right ventricle could foreshadow heart failure and cardiovascular death

Date:
September 6, 2012
Source:
Perelman School of Medicine at the University of Pennsylvania
Summary:
Researchers report in a new study that thickening of the heart's right ventricle is associated with an increased risk of heart failure and cardiovascular death in patients without clinical cardiovascular disease at baseline. The study is published online ahead of print in the journal Circulation.

Researchers at the Perelman School of Medicine at the University of Pennsylvania report in a new study that thickening of the heart's right ventricle is associated with an increased risk of heart failure and cardiovascular death in patients without clinical cardiovascular disease at baseline.

The study is published online ahead of print in the journal Circulation.

"In most studies of the heart, researchers have focused on the more-easily-imaged left ventricle, the region of the heart affected by systemic high blood pressure and other common conditions," said study author Steven Kawut, M.D., M.S., associate professor of Medicine and Epidemiology and director of the Pulmonary Vascular Disease Program at Penn. "But we know from the results of this study and previous work that focusing attention on the right ventricle (RV) is critical in our understanding of many conditions of the heart and lungs. This research revealed that approximately one in 10 heart failure events and cardiovascular deaths may be attributed to thickening of the RV in adults without clinical cardiovascular disease at baseline."

The researchers examined cardiac magnetic resonance (CMR) images of the right ventricles of 4,144 men and women, average age 61, participating in the Multi-Ethnic Study of Atherosclerosis (MESA). The MESA is a multicenter research project tracking the development of cardiovascular disease in 6,814 Caucasians, African-Americans, Hispanics and Chinese-Americans who did not have clinically-diagnosed heart disease at the beginning of the study.

Participants with RV hypertrophy (or abnormal thickening of the RV) had double the risk of heart failure or death compared to those with normal RV size. This association persisted after adjustment for age, sex, race/ethnicity, body mass index, education, smoking status, and other clinical indicators. This relationship was strongest in those with average or lower left ventricular mass.

"These findings run counter to the traditional belief that for otherwise-healthy adults, the RV plays a limited role in clinical heart failure," said Kawut, who is also a member of the Penn Cardiovascular Institute. "The strong association our study found warrants further studies of the role of the RV in contributing to the risk of adverse outcomes. The MESA has repeated CMR images in these same participants ten years later, so our next goals are to understand the changes in the RV over time and how this tracks with how adults feel, function, and survive."

This work was funded by several National Institutes of Health grants and contracts including R01-HL086719, R01-HL077612, K24- HL103844, and N01-HC95159 through N01-HC95169.


Story Source:

The above story is based on materials provided by Perelman School of Medicine at the University of Pennsylvania. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. M. Kawut, R. G. Barr, J. A. C. Lima, A. Praestgaard, W. C. Johnson, H. Chahal, K. O. Ogunyankin, M. R. Bristow, J. R. Kizer, H. Tandri, D. A. Bluemke. Right Ventricular Structure is Associated with the Risk of Heart Failure and Cardiovascular Death: The MESA-Right Ventricle Study. Circulation, 2012; DOI: 10.1161/CIRCULATIONAHA.112.095216

Cite This Page:

Perelman School of Medicine at the University of Pennsylvania. "Thickening of the heart's right ventricle could foreshadow heart failure and cardiovascular death." ScienceDaily. ScienceDaily, 6 September 2012. <www.sciencedaily.com/releases/2012/09/120906111747.htm>.
Perelman School of Medicine at the University of Pennsylvania. (2012, September 6). Thickening of the heart's right ventricle could foreshadow heart failure and cardiovascular death. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/09/120906111747.htm
Perelman School of Medicine at the University of Pennsylvania. "Thickening of the heart's right ventricle could foreshadow heart failure and cardiovascular death." ScienceDaily. www.sciencedaily.com/releases/2012/09/120906111747.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins