Featured Research

from universities, journals, and other organizations

Genetic test will help dose blood thinner

Date:
September 6, 2012
Source:
University of Illinois at Chicago
Summary:
Patients suffering from dangerous blood clots will receive genetic testing to help health professionals at the University of Illinois Hospital & Health Sciences System prescribe the proper dose of the blood-thinner warfarin.

Patients suffering from dangerous blood clots will receive genetic testing to help health professionals at the University of Illinois Hospital & Health Sciences System prescribe the proper dose of the blood-thinner warfarin.

The UI Health System is one of the first in the nation to use genetic information to help patients receive the right dose of the drug, which consistently ranks among the leading causes of serious drug-related adverse events.

The genetic test will identify common variants in CYP2C9, an enzyme that breaks down warfarin, and VKORC1, a clotting enzyme that is the target of warfarin, says Larisa Cavallari, UIC associate professor of pharmacy practice and one of the co-directors of the new program.

The ultimate goal, Cavallari said, is to provide personalized medicine to patients, customized to account for their unique genetic ancestry.

"The majority of pharmacogenetic research and use of pharmacogenetics in clinical practice in the United States has been in populations of European descent," says Edith Nutescu, UIC clinical professor of pharmacy practice and co-director of the program. "We're confident that genotype-guided pharmacotherapy in urban, underserved populations will improve the effectiveness and safety of medications."

Warfarin is difficult to dose, and is usually begun at similar amounts for all patients, Cavallari said. It It is prescribed to treat deep vein thrombosis and pulmonary embolism and to prevent stroke as a result of atrial fibrillation or heart valve replacement. It carries a "black-box" warning from the Food and Drug Administration for bleeding risk.

The pharmacogenetics project is a collaboration between the UIC colleges of Pharmacy and of Medicine, including the latter's cardiology, medicine, hematology and clinical pathology departments. In addition to Cavallari and Nutescu, other directors include Dr. William Galanter, assistant professor of clinical medicine; Carol Dodge, manager of the UI Health Molecular Pathology Laboratory; Dr. Victor Gordeuk, professor of hematology/oncology; Dr. Shrihari Kadkol, associate professor of pathology; and Dr. Thomas Stamos, associate professor of medicine.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Genetic test will help dose blood thinner." ScienceDaily. ScienceDaily, 6 September 2012. <www.sciencedaily.com/releases/2012/09/120906181656.htm>.
University of Illinois at Chicago. (2012, September 6). Genetic test will help dose blood thinner. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2012/09/120906181656.htm
University of Illinois at Chicago. "Genetic test will help dose blood thinner." ScienceDaily. www.sciencedaily.com/releases/2012/09/120906181656.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins