Featured Research

from universities, journals, and other organizations

'Smart bomb' investigational breast cancer regimen provides promising outcome for retired minister

Date:
September 14, 2012
Source:
Methodist Hospital, Houston
Summary:
A 66-year-old Houston woman's golf ball-sized breast tumor is now almost invisible to the naked eye after only four rounds of an investigational drug regimen.

A 66-year-old Houston woman's golf ball-sized breast tumor is now almost invisible to the naked eye after only four rounds of an investigational drug regimen.

Dr. Jenny Chang, director of the Methodist Cancer Center and breast medical oncologist, said the results are promising but no conclusions can be made because this is an ongoing study and the patient is the first at Methodist to be enrolled.

The Rev. Noel Denison, a retired Methodist minister, was diagnosed with locally advanced HER2-positive breast cancer and is enrolled in the study at Methodist, one of only two locations in the United States. The clinical trial is for locally advanced or metastatic HER2-positive breast cancer and combines standard chemotherapy with trastuzumab emtansine, better known in the breast cancer world as T-DM1, and pertuzumab, a monoclonal antibody that also attaches to HER2 on cancer cells.

T-DM1 is in a new class of cancer-fighting agents called antibody drug conjugates. By combining the antibody trastuzumab directly with docetaxel (standard chemotherapy) and/or pertuzumab, the T-DMI is designed to attack the tumor cells directly and deliver the chemotherapy.

"Women with HER2-positive breast cancer now have a lot of opportunities for treatment," said Chang, the study's principal investigator at Methodist. "Trastuzumab, commonly known as herceptin, is good, but we're hopeful that this combination we're using, known as a super herceptin, is even better at targeting and killing the cancer cells."

Study patients receive T-DM1 and docetaxel on day 1 of each 3-week cycle (up to six cycles). For patients with locally advanced breast cancer, pertuzumab may be added to T-DM1 and docetaxel. Sold as Perjeta, pertuzumab is an FDA-approved drug used in combination with herceptin and docetaxel to treat certain patients with HER2-positive metastatic breast cancer.

Previous research involving more than 1,000 women with advanced HER-2 breast cancer showed T-DM1 caused fewer and less harsh side effects than current standard treatment.

Five months after her initial diagnosis, Denison is still undergoing the experimental regimen, but she is back to the things she loves -- gardening, volunteering in her community and spending time with her grandchildren.

"I'm also putting my time and energy into breast cancer education," Denison said. "I live with the pay it forward attitude. The Methodist Cancer Center gave so much to me; it is only fitting to give back to others in need."

Genentech Inc./F. Hoffmann La Roche Ltd. is funding this clinical trial.


Story Source:

The above story is based on materials provided by Methodist Hospital, Houston. Note: Materials may be edited for content and length.


Cite This Page:

Methodist Hospital, Houston. "'Smart bomb' investigational breast cancer regimen provides promising outcome for retired minister." ScienceDaily. ScienceDaily, 14 September 2012. <www.sciencedaily.com/releases/2012/09/120914135327.htm>.
Methodist Hospital, Houston. (2012, September 14). 'Smart bomb' investigational breast cancer regimen provides promising outcome for retired minister. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2012/09/120914135327.htm
Methodist Hospital, Houston. "'Smart bomb' investigational breast cancer regimen provides promising outcome for retired minister." ScienceDaily. www.sciencedaily.com/releases/2012/09/120914135327.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins