Featured Research

from universities, journals, and other organizations

Prenatal damage from dioxin shown to involve microRNAs

Date:
September 17, 2012
Source:
University of South Carolina
Summary:
New research has identified novel mechanisms through which dioxin can alter physiological functions.

Research carried out at the University of South Carolina has identified novel mechanisms through which dioxin, a well-known environmental contaminant, can alter physiological functions, according to a study published online in the journal PLOS ONE.

The research team, which included Narendra Singh, Mitzi Nagarkatti and Prakash Nagarkatti of the USC School of Medicine, demonstrated that exposure to dioxin (TCDD) during pregnancy in an experimental mouse model can cause significant toxicity to the fetus, and specifically to the organs that produce the immune cells that fight infections. They found that dioxin alters small molecules called microRNAs, which can affect the expression of a large number of genes.

The study examined over 608 microRNAs, and 78 of these were significantly altered following exposure to dioxin. On the basis of the pattern of changes in these molecules, the team was also able to predict that dioxin can alter several genes that regulate cancer. Many other physiological systems were also affected, including those involved in reproductive, gastrointestinal, hematological, inflammation, renal and urological diseases as well as genetic, endocrine and developmental disorders.

Dioxin is a highly toxic chemical produced as a byproduct of industrial processes, such as the manufacture of herbicides or pesticides or the bleaching of paper. Because it degrades slowly in the environment and is soluble in fats, dioxin can bio-accumulate in the food chain and is often found in high concentrations in the milk and fat of animals in contaminated regions.

"Our results lend more credence to the hypothesis that fetal exposure to environmental contaminants can have life-long effects," said Mitzi Nagarkatti. "Prenatal damage to the expression of microRNAs in the immune system could well impact the adult immune response."

The research was supported in part by the National Institutes of Health (R01ES09098, P01AT003961, R01AT006888, R01ES019313, R01MH094755) and the Veterans Administration (VA Merit Award 1I01BX001357).


Story Source:

The above story is based on materials provided by University of South Carolina. Note: Materials may be edited for content and length.


Journal Reference:

  1. Narendra P. Singh, Udai P. Singh, Hongbing Guan, Prakash Nagarkatti, Mitzi Nagarkatti. Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression. PLoS ONE, 2012; 7 (9): e45054 DOI: 10.1371/journal.pone.0045054

Cite This Page:

University of South Carolina. "Prenatal damage from dioxin shown to involve microRNAs." ScienceDaily. ScienceDaily, 17 September 2012. <www.sciencedaily.com/releases/2012/09/120917124345.htm>.
University of South Carolina. (2012, September 17). Prenatal damage from dioxin shown to involve microRNAs. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2012/09/120917124345.htm
University of South Carolina. "Prenatal damage from dioxin shown to involve microRNAs." ScienceDaily. www.sciencedaily.com/releases/2012/09/120917124345.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins