Featured Research

from universities, journals, and other organizations

Biological markers increase clinical trial success rate of new breast cancer drugs

Date:
October 1, 2012
Source:
University of Toronto
Summary:
Using biological markers -- genetic characteristics that are associated with some patients with breast cancer -- can increase the success rate of clinical trials for breast cancer drugs by almost 50 per cent, says new research.

Using biological markers -- genetic characteristics that are associated with some patients with breast cancer -- can increase the success rate of clinical trials for breast cancer drugs by almost 50 per cent, says new research from the University of Toronto Mississauga.

"It's been increasingly difficult for pharmaceutical companies to bring new drugs to market," says Jayson Parker, a faculty member in the Department of Biology and medical biotechnology analyst at the University of Toronto. "On average, about 80 per cent of drugs fail at some point in the clinical trial process."

There are currently no clear estimates of success rates in clinical trials for breast cancer drugs and the factors that can impact success. The research team examined clinical trial drug development programs from 1998 to 2012 to determine how often breast cancer drugs were brought to market. The study examined advanced and metastatic breast cancer as well as patients that have been exposed to the chemotherapy drugs taxane and anthracycline.

"We found that only 14 per cent of drugs that undergo human testing for advanced and metastatic breast cancer are eventually approved," says Parker. "This is worse than the average for the industry as a whole."

According to Parker, some researchers have hypothesized that in the era of personalized medicine, biological markers, or biomarkers, could be used to improve clinical trial success rates and help bring more drugs to market faster. To test this hypothesis, Parker and his team examined the clinical trial success rates for drugs tested on breast cancer patients who have a particular biomarker (HER2). Biomarkers form part of the pathway involved in cancer cell development and can influence how a patient responds to therapy.

When the team compared clinical trials that targeted patients with the HER2 biomarker to those that did not, they found the success rate of drug development increased from 15 per cent to 23 per cent.

Improving the success rate of clinical trials also has an economic impact. Parker's team found that using the HER2 biomarker in the design of clinical trials resulted in a cost savings of 27 per cent. "This can means millions of dollars in cost reduction for a clinical trial," says Parker.

Although this finding may be limited to the HER2 biomarker in breast cancer, Parker says the results are encouraging. "This is the first study that has made a systematic comparison between patients with and without a biomarker," he says. "It provides us with concrete initial evidence that the use of a biomarker can help improve clinical trial success rates in breast cancer. We are now exploring whether this finding holds true for other biomarkers in other cancers."

Parker conducted the study with graduate students in the Master of Biotechnology program (MBiotech), Nadia Lushina and Prabjot Bal, along with an oncologist at Johns Hopkins Medical School, Dr. Gilberto Lopes and oncologists at Sunnybrook Health Sciences Centre, Dr. Rebecca Dent and Dr. Teresa Petrella.


Story Source:

The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jayson L. Parker, Nadia Lushina, Prabjot S. Bal, Teresa Petrella, Rebecca Dent, Gilberto Lopes. Impact of biomarkers on clinical trial risk in breast cancer. Breast Cancer Research and Treatment, 2012; DOI: 10.1007/s10549-012-2247-6

Cite This Page:

University of Toronto. "Biological markers increase clinical trial success rate of new breast cancer drugs." ScienceDaily. ScienceDaily, 1 October 2012. <www.sciencedaily.com/releases/2012/10/121001125415.htm>.
University of Toronto. (2012, October 1). Biological markers increase clinical trial success rate of new breast cancer drugs. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2012/10/121001125415.htm
University of Toronto. "Biological markers increase clinical trial success rate of new breast cancer drugs." ScienceDaily. www.sciencedaily.com/releases/2012/10/121001125415.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins