Featured Research

from universities, journals, and other organizations

Scientists develop novel technology to identify biomarkers for ulcerative colitis

Date:
October 3, 2012
Source:
Scripps Research Institute
Summary:
Scientists have developed a novel technology that can identify, in animal models, potential biomarkers of ulcerative colitis, a type of inflammatory bowel disease that affects the lining of the colon.

cientists from the Florida campus of The Scripps Research Institute have developed a novel technology that can identify, in animal models, potential biomarkers of ulcerative colitis, a type of inflammatory bowel disease that affects the lining of the colon.

The study was published October 3, 2012, in the Journal of the American Chemical Society.

The new research focuses on the protein arginine deiminases (PAD), which have been implicated in a number of diseases, including cancer, multiple sclerosis and rheumatoid arthritis. PADs participate in reactions in the body that form the amino acid citrulline in proteins through a process known as citrullination. This modification can have significant effects on the structure and function of the modified proteins.

While abnormally high PAD activity is present in a host of human diseases, the exact role of citrullination in these diseases remains unknown, largely due to the lack of readily available chemical probes to study it.

"We have developed technology to identify biomarkers for a variety of diseases in which you see abnormal PAD activity," said Paul Thompson, an associate professor in the Department of Chemistry at Scripps Research, who led the study. "This identification of potential biomarkers in animal models of ulcerative colitis is really the first step in a much larger effort. We want to push forward into rheumatoid arthritis and cancer to look for different diagnostic markers in these disease situations."

In the new study, the scientists describe a chemical probe called rhodamine‐phenylglyoxal (Rh‐PG), which tags citrulline-containing proteins with a fluorescent imaging compound.

According to Thompson, the next step will be to produce further generations of this chemical probe to isolate the biomarker proteins and determine their sites of modification, as well as to quantify the extent of the citrullination.


Story Source:

The above story is based on materials provided by Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kevin L. Bicker, Venkataraman Subramanian, Alexander A. Chumanevich, Lorne J. Hofseth, Paul R. Thompson. Seeing Citrulline: Development of a Phenylglyoxal-Based Probe To Visualize Protein Citrullination. Journal of the American Chemical Society, 2012; 121003073113002 DOI: 10.1021/ja308871v

Cite This Page:

Scripps Research Institute. "Scientists develop novel technology to identify biomarkers for ulcerative colitis." ScienceDaily. ScienceDaily, 3 October 2012. <www.sciencedaily.com/releases/2012/10/121003195212.htm>.
Scripps Research Institute. (2012, October 3). Scientists develop novel technology to identify biomarkers for ulcerative colitis. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/10/121003195212.htm
Scripps Research Institute. "Scientists develop novel technology to identify biomarkers for ulcerative colitis." ScienceDaily. www.sciencedaily.com/releases/2012/10/121003195212.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins