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Are inhaled medications effective and safe in critically ill patients on mechanical ventilation?

Date:
October 4, 2012
Source:
Mary Ann Liebert, Inc., Publishers
Summary:
Essential medications can be delivered as inhaled drugs to critically ill patients in the ICU who require mechanical ventilation to breathe. Aerosol drug delivery is highly complex, and if not done properly the medication will not reach the lungs and therapy will be ineffective. Researchers have reviewed the efficacy and safety of aerosol delivery of drugs used in the ICU.

Essential medications can be delivered as inhaled drugs to critically ill patients in the Intensive Care Unit (ICU) who require mechanical ventilation to breathe. Aerosol drug delivery is highly complex, however, and if not done properly the medication will not reach the lungs and therapy will be ineffective. The efficacy and safety of aerosol delivery of drugs commonly used in the ICU such as antibiotics, diuretics, and anticoagulants is explored in depth in a review article published in Journal of Aerosol Medicine and Pulmonary Drug Delivery.

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Arzu Ari, PhD, RRT and James Fink, PhD, RRT, Georgia State University (Atlanta) and Rajiv Dhand, MD, University of Tennessee Graduate School of Medicine (Knoxville) state that the successful use of bronchodilator therapy in ventilator-dependent patients has led to growing interest in the delivery of other aerosolized forms of medication to improve outcomes for patients in the ICU that require mechanical ventilation. In the article "Inhalation Therapy in Patients Receiving Mechanical Ventilation: An Update" the authors explore the complexities of aerosol therapy in this patient population and the advances in drug delivery devices that are contributing to its increasing use and success.

"Newer drugs, such as antibiotics, will require better control of dose and delivery if they are to be successful in treating the intubated patient." says Editor-in-Chief Gerald C. Smaldone, MD, PhD, Professor and Chief, Division of Pulmonary and Critical Care Medicine at SUNY-Stony Brook.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc., Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arzu Ari, James B. Fink, Rajiv Dhand. Inhalation Therapy in Patients Receiving Mechanical Ventilation: An Update. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2012; 120802092113007 DOI: 10.1089/jamp.2011.0936

Cite This Page:

Mary Ann Liebert, Inc., Publishers. "Are inhaled medications effective and safe in critically ill patients on mechanical ventilation?." ScienceDaily. ScienceDaily, 4 October 2012. <www.sciencedaily.com/releases/2012/10/121004134841.htm>.
Mary Ann Liebert, Inc., Publishers. (2012, October 4). Are inhaled medications effective and safe in critically ill patients on mechanical ventilation?. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2012/10/121004134841.htm
Mary Ann Liebert, Inc., Publishers. "Are inhaled medications effective and safe in critically ill patients on mechanical ventilation?." ScienceDaily. www.sciencedaily.com/releases/2012/10/121004134841.htm (accessed April 1, 2015).

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