Featured Research

from universities, journals, and other organizations

More about spatial memory problems associated with Alzheimer's revealed

Date:
October 10, 2012
Source:
University of Western Ontario
Summary:
Researchers have created a mouse model that reproduces some of the chemical changes in the brain that occur with Alzheimer's, shedding new light on this devastating disease.

Researchers at Western University have created a mouse model that reproduces some of the chemical changes in the brain that occur with Alzheimer's, shedding new light on this devastating disease. Marco Prado, Vania Prado and their colleagues at the Schulich School of Medicine & Dentistry's Robarts Research Institute, looked at changes related to a neurotransmitter or chemical messenger, named acetylcholine (ACh), and the kinds of memory problems associated with it.

Related Articles


The research is now published online by PNAS.

The researchers, including first author Amanda Martyn, created a mouse line that doesn't have enough ACh being secreted by neurons in the same brain regions affected by Alzheimer's disease. They found this neurochemical failure caused problems with spatial memory, the stored information that is needed for navigating one's environment. For instance, the memory needed to drive across town. They also found the reduction of ACh led to hyperactivity, which many patients with Alzheimer's experience.

"Once we reproduced that neurochemical failure, we asked, 'how does that affect spatial memory, how does it affect learning?' We found mice that don't have that particular chemical messenger in specific areas of the brain, have problems with spatial memory, for example," says Marco Prado. "This reveals specific types of cognitive deficits that we can hope to improve with drugs that boost this chemical messenger."


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. C. Martyn, X. De Jaeger, A. C. Magalhaes, R. Kesarwani, D. F. Goncalves, S. Raulic, M. S. Guzman, M. F. Jackson, I. Izquierdo, J. F. MacDonald, M. A. M. Prado, V. F. Prado. Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1215381109

Cite This Page:

University of Western Ontario. "More about spatial memory problems associated with Alzheimer's revealed." ScienceDaily. ScienceDaily, 10 October 2012. <www.sciencedaily.com/releases/2012/10/121010131538.htm>.
University of Western Ontario. (2012, October 10). More about spatial memory problems associated with Alzheimer's revealed. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2012/10/121010131538.htm
University of Western Ontario. "More about spatial memory problems associated with Alzheimer's revealed." ScienceDaily. www.sciencedaily.com/releases/2012/10/121010131538.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins