Featured Research

from universities, journals, and other organizations

Is immediate and long-term pain after a motor vehicle collision hereditary?

Date:
October 16, 2012
Source:
American Society of Anesthesiologists (ASA)
Summary:
Two studies have found that hereditary genes were responsible for the amount and type of pain experienced after a motor vehicle collision (MVC). Many drivers experience symptoms after an MVC, including musculoskeletal pain in the back, neck and other areas. It has been unknown why some drivers feel pain immediately after a collision or develop persistent pain after a collision, while others do not.

Two studies presented at the ANESTHESIOLOGY™ 2012 annual meeting found that hereditary genes were responsible for the amount and type of pain experienced after a motor vehicle collision (MVC). Many drivers experience symptoms after an MVC, including musculoskeletal pain in the back, neck and other areas. It has been unknown why some drivers feel pain immediately after a collision or develop persistent pain after a collision, while others do not.

Previous studies suggest the etiology of pain after an MVC is not solely due to tissue damage at the time of trauma, but rather may also be strongly influenced by physiologic systems involved in the body's response to the collision. These physiologic systems influence the function of nerve cells that process pain in the brain, spinal cord and body tissues.

Researchers from the University of North Carolina collected data from 948 patients who came to one of eight emergency departments in four states for care after an MVC. Participants provided a blood sample at the time of their emergency department evaluation. The extent and severity of patient pain symptoms were assessed at the time of the emergency department visit and also six weeks after the emergency department visit (via a telephone or web-based interview). The researchers used the data for two separate studies.

The first study analyzed the role of dopamine, an important neurotransmitter in the brain. Out of the five different dopamine receptors, dopamine receptor 2 has been shown to play an important role in neurologic function. The first study assessed whether genetic variations influencing the function of the dopamine receptor 2 are associated with acute pain severity after an MVC. One specific single nucleotide polymorphism in the dopamine receptor 2, rs6276, was significantly associated with pain severity in the acute aftermath of a collision.

"The findings suggest dopamine pathways involving the dopamine receptor 2 contribute to the intensity of pain experienced immediately after an MVC," said study author Andrey V. Bortsov, M.D., Ph.D., Assistant Professor of Anesthesiology, University of North Carolina, Chapel Hill.

The second study assessed the role of the hypothalamic-pituitary adrenal (HPA) axis, a physiologic system of central importance to the body's response to stressful events. The study evaluated whether the HPA axis influences pain severity six weeks after MVC. Findings revealed the FKBP5 gene variant was associated with a 20 percent higher risk of moderate to severe neck pain six weeks after an MVC, as well as a greater extent of body pain.

"Unfortunately, patients who experience persistent pain after an MVC are often viewed with suspicion, as if they are making up their symptoms for financial gain or some other reason," said senior study author Samuel A. McLean, M.D., Assistant Professor of Anesthesiology, University of North Carolina, Chapel Hill. "Our study is the first to identify a genetic risk factor for persistent pain after an MVC, and contributes further evidence that persistent pain after a collision has a neurobiological basis. These findings also will help us begin to identify physiologic systems involved in chronic pain development after an MVC. Understanding these systems will help us to develop new interventions to prevent the transition from acute to chronic pain after a collision."


Story Source:

The above story is based on materials provided by American Society of Anesthesiologists (ASA). Note: Materials may be edited for content and length.


Cite This Page:

American Society of Anesthesiologists (ASA). "Is immediate and long-term pain after a motor vehicle collision hereditary?." ScienceDaily. ScienceDaily, 16 October 2012. <www.sciencedaily.com/releases/2012/10/121016131500.htm>.
American Society of Anesthesiologists (ASA). (2012, October 16). Is immediate and long-term pain after a motor vehicle collision hereditary?. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/10/121016131500.htm
American Society of Anesthesiologists (ASA). "Is immediate and long-term pain after a motor vehicle collision hereditary?." ScienceDaily. www.sciencedaily.com/releases/2012/10/121016131500.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
How Detroit's Money Woes Led To U.N.-Condemned Water Cutoffs

How Detroit's Money Woes Led To U.N.-Condemned Water Cutoffs

Newsy (Oct. 20, 2014) The United Nations says water is a human right, but should it be free? Detroit has cut off water to residents who can't pay, and the U.N. isn't happy. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins