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Daily multivitamins reduce risk of cancer in men: Study is first to examine long-term affect of multivitamins on major chronic disease

Date:
October 17, 2012
Source:
Brigham and Women's Hospital
Summary:
A daily multivitamin can help a man reduce his risk of cancer, according to new research.

A daily multivitamin can help a man reduce his risk of cancer, according to new research from Brigham and Women's Hospital (BWH). The first-of-its kind study will be presented October 17 at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research and published online the same day in the Journal of the American Medical Association.

"The Physicians' Health Study II is the first clinical trial to test the affects of multivitamins on a major disease such as cancer," said lead author J. Michael Gaziano, MD, chief of the Division of Aging at BWH and an investigator at VA Boston. "Despite the fact that more than one-third of Americans take multivitamins, their long-term effects were unknown until now."

Researchers had nearly 15,000 men over the age of 50 take either a multivitamin or a placebo every day for more than 10 years. The men self-reported a cancer diagnosis, and researchers confirmed the diagnosis through medical records. Researchers found the group taking a daily multivitamin had an 8 percent reduction in total cancer compared with the group taking the placebo. They also found a multivitamin was associated with an apparent reduction in cancer deaths.

Study co-author Howard D. Sesso, ScD, an associate epidemiologist in the Division of Preventive Medicine at BWH said, "Many studies have suggested that eating a nutritious diet may reduce a man's risk of developing cancer. Now we know that taking a daily multivitamin, in addition to addressing vitamin and mineral deficiencies, may also be considered in the prevention of cancer in middle-aged and older men."

Researchers point out that it is not clear which specific vitamins or minerals in a multivitamin may be responsible for the reduction in cancer risk. Also, it is not known if the results can extend to women or to men younger than the age of 50. Researchers plan to follow up with study participants to determine the affect of a daily multivitamin on cancer over an even longer period of time.

A similar study is examining the affect of daily multivitamin use on cardiovascular disease risk. Results of that study will be announced at the American Heart Association Scientific Sessions in early November.

This research was supported by grants CA 097193, CA 34944, CA 40360, HL 26490, and HL 34595 from the National Institutes of Health, and an investigator-initiated grant from BASF Corporation. Study agents and packaging were provided by BASF Corporation and Pfizer (formerly Wyeth, American Home Products, and Lederle). Study packaging was provided by DSM Nutritional Products, Inc. (formerly Roche Vitamins).


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gaziano J, Sesso HD, Christen WG, et al. Multivitamins in the Prevention of Cancer in Men: The Physicians' Health Study II Randomized Controlled Trial. JAMA, 2012; DOI: 10.1001/jama.2012.14641

Cite This Page:

Brigham and Women's Hospital. "Daily multivitamins reduce risk of cancer in men: Study is first to examine long-term affect of multivitamins on major chronic disease." ScienceDaily. ScienceDaily, 17 October 2012. <www.sciencedaily.com/releases/2012/10/121017123912.htm>.
Brigham and Women's Hospital. (2012, October 17). Daily multivitamins reduce risk of cancer in men: Study is first to examine long-term affect of multivitamins on major chronic disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2012/10/121017123912.htm
Brigham and Women's Hospital. "Daily multivitamins reduce risk of cancer in men: Study is first to examine long-term affect of multivitamins on major chronic disease." ScienceDaily. www.sciencedaily.com/releases/2012/10/121017123912.htm (accessed October 21, 2014).

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Multivitamin Use Among Middle-Aged, Older Men Results in Modest Reduction in Cancer, Study Finds

Oct. 17, 2012 In a randomized trial that included nearly 15,000 male physicians, long-term daily multivitamin use resulted in a modest but statistically significant reduction in cancer after more than a decade of ... read more

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