Featured Research

from universities, journals, and other organizations

Damage to blood vessel lining may account for kidney failure patients' heart risks

Date:
October 18, 2012
Source:
American Society of Nephrology (ASN)
Summary:
Individuals with kidney failure often develop heart problems, but it's not clear why. A new study provides evidence that their kidneys' inability to excrete waste products in the urine, which leads to build-up of these products in the blood, may damage the sugary lining of blood vessels and lead to heart troubles.

Individuals with kidney failure often develop heart problems, but it's not clear why. A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN) provides evidence that their kidneys' inability to excrete waste products in the urine, which leads to build-up of these products in the blood, may damage the sugary lining of blood vessels and lead to heart troubles.

Carmen Vlahu (an MD/PhD student at the Academic Medical Center Amsterdam, in the Netherlands) and her colleagues wondered whether the "glycocalyx," a sugar layer coating the insides of blood vessels, is damaged in patients with kidney failure and is responsible for their increased risks of heart problems. To investigate, they used a newly developed imaging method to look at 40 patients' and 21 healthy individuals' blood vessels. They also measured participants' blood levels of glycocalyx constituents.

Compared with healthy individuals, kidney failure patients had lost some of the glycocalyx coating the insides of their blood vessels, and they had high levels of glycocalyx constituents in their blood, consistent with increased shedding of glycocalyx from blood vessel walls.

"Impaired glycocalyx barrier properties, together with shedding of its constituents into the blood, probably contribute to the aggressive vascular pathology present in this group of patients," said Vlahu. "The state of endothelial glycocalyx and its circulating components could provide valuable tools to monitor vascular vulnerability, to detect early stages of disease, to evaluate risk, and to judge the response of patients with kidney disease to treatment," she added.

Study co-authors include Bregtje A. Lemkes, MD, PhD, Dirk G. Struijk, MD, PhD, Marion G. Koopman, MD, PhD, Raymond T. Krediet, MD, PhD, and Hans Vink, PhD.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Carmen A. Vlahu, Bregtje A. Lemkes, Dirk G. Struijk, Marion G. Koopman, Raymond T. Krediet, and Hans Vink. Damage of the Endothelial Glycocalyx in Dialysis Patients. Journal of the American Society of Nephrology, 2012; DOI: 10.1681/ASN.2011121181

Cite This Page:

American Society of Nephrology (ASN). "Damage to blood vessel lining may account for kidney failure patients' heart risks." ScienceDaily. ScienceDaily, 18 October 2012. <www.sciencedaily.com/releases/2012/10/121018184848.htm>.
American Society of Nephrology (ASN). (2012, October 18). Damage to blood vessel lining may account for kidney failure patients' heart risks. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/10/121018184848.htm
American Society of Nephrology (ASN). "Damage to blood vessel lining may account for kidney failure patients' heart risks." ScienceDaily. www.sciencedaily.com/releases/2012/10/121018184848.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins