Featured Research

from universities, journals, and other organizations

Chronic kidney disease increases risk of death at all ages, study finds

Date:
October 31, 2012
Source:
Johns Hopkins University Bloomberg School of Public Health
Summary:
A new study finds chronic kidney disease and its complications were associated with a higher risk of death regardless of age.

A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that chronic kidney disease and its complications were associated with a higher risk of death regardless of age. The findings were presented October 30 at the American Society of Nephrology conference in San Diego, Ca. and published in latest issue of JAMA.

Chronic kidney disease prevalence increases dramatically with age from 4 percent at age 20-39 to 54 percent of adults over age 75 in the populations studied. This led some groups to question whether kidney disease at older ages is associated with increased risk and even whether the accepted definition of chronic kidney disease should be changed. Kidney disease is measured by estimating kidney function (glomerular filtration rate, GFR), and kidney damage is often quantified by measuring albumin, the major protein in the urine standardized for urine concentration.

According to the study, both low kidney function and high albuminuria were independently associated with mortality and end-stage renal disease regardless of age. Among the general populations examined and groups at high risk for kidney disease, the study found that relative mortality risk decreased with age in participants with low kidney function while absolute excess risk increased. For participants with high albuminuria, the reductions in relative risk were less apparent while increases in absolute risk were higher among older participants.

"By collaborating with many of the world's leading studies, we were able to see a clear pattern showing that both of the current indicators of chronic kidney disease are strongly associated with risk, even at older age," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.

For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies conducted during 1972 to 2011. The study participants included a diverse population from Asia, Australia, Europe, and North and South America. Stein Hallan, a nephrologist from Norway, who led the writing of the manuscript on behalf of the 178 collaborating investigators said, "This analysis put to bed the controversy about kidney disease among older adults and the hypothesis that chronic kidney disease is so common at old age that it must be 'normal.' Instead we need to focus on the range of risks at each age and potential strategies to help patients minimize unnecessary exposure to medications toxic to the kidney and pursue other strategies to best treat kidney disease across the full age spectrum."

"Age and the Association of Kidney Measures with Mortality and End-Stage Renal Disease" written by the Chronic Kidney Disease Prognosis Consortium (CKD-PC), which includes approximately 200 collaborators and data from 40 countries.

The U.S. National Kidney Foundation and a variety of sources such as national institutes of health and medical research councils as well as foundations and industry sponsors supporting the authors and collaborating cohorts of the CKD-PC.


Story Source:

The above story is based on materials provided by Johns Hopkins University Bloomberg School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hallan SI, Matsushita K, Sang Y, et al. Age and Association of Kidney Measures With Mortality and End-stage Renal Disease. JAMA, 2012; DOI: 10.1001/jama.2012.16817

Cite This Page:

Johns Hopkins University Bloomberg School of Public Health. "Chronic kidney disease increases risk of death at all ages, study finds." ScienceDaily. ScienceDaily, 31 October 2012. <www.sciencedaily.com/releases/2012/10/121031142011.htm>.
Johns Hopkins University Bloomberg School of Public Health. (2012, October 31). Chronic kidney disease increases risk of death at all ages, study finds. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2012/10/121031142011.htm
Johns Hopkins University Bloomberg School of Public Health. "Chronic kidney disease increases risk of death at all ages, study finds." ScienceDaily. www.sciencedaily.com/releases/2012/10/121031142011.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins