Featured Research

from universities, journals, and other organizations

High fever and evidence of a virus? Caution, it still may be Kawasaki disease

Date:
November 5, 2012
Source:
Nationwide Children's Hospital
Summary:
Clinicians should take caution when diagnosing a child who has a high fever and whose tests show evidence of adenovirus, and not assume the virus is responsible for Kawasaki-like symptoms. According to a new study, adenovirus detection is not uncommon among children with Kawasaki disease.

Clinicians should take caution when diagnosing a child who has a high fever and whose tests show evidence of adenovirus, and not assume the virus is responsible for Kawasaki-like symptoms. According to a new study from Nationwide Children's Hospital appearing in Clinical Infectious Diseases, adenovirus detection is not uncommon among children with Kawasaki disease.

Kawasaki disease is a rare but serious condition in children that involves inflammation of the blood vessels, specifically the heart vessels that supply the heart tissue or coronary arteries. It is the most common cause of pediatric acquired heart disease in the developed world. Children with Kawasaki disease or illness caused by adenoviruses often first present with a high and persistent fever. Early diagnosis for Kawasaki disease before the tenth day of fever is essential to prevent sequelae in the heart.

"Kawasaki disease and acute adenoviral infection can present with many of the same clinical characteristics," says Preeti Jaggi, MD, member of the Section of Infectious Diseases at Nationwide Children's and lead study author. "Given the similarities, human adenovirus infection is one of the most frequent conditions included on the differential diagnosis when considering Kawasaki disease." However, few data are available regarding the differences in frequency, viral load and types of detectable human adenovirus in Kawasaki disease patients and in children who have adenovirus disease that mimicks Kawasaki disease.

The study aimed to determine whether there are differences in the amount of human adenovirus in the upper airway in children with human adenovirus infection versus those diagnosed with Kawasaki disease. Dr. Jaggi and her team compared Kawasaki disease patients who were positive for human adenovirus infection with other patients diagnosed with human adenovirus infection during a two year period at Nationwide Children's. Among 77 Kawasaki disease patients, nearly 13 percent had human adenovirus detected.

"Evidence suggests that human adenovirus strains can persist in pediatric adenoids and tonsils and are capable of low level shedding. PCR analysis can detect non-replicating virus," says Dr. Jaggi, also assistant professor of Clinical Pediatrics at The Ohio State University College of Medicine. "This may explain why PCR, but not viral culture, could detect human adenovirus in these Kawasaki disease patients."

The findings indicate that detection of human adenovirus in a patient with suspected Kawasaki disease should be interpreted with caution. "Detection of human adenovirus in these patients is fairly common and does not exclude the diagnosis of Kawasaki disease," says Dr. Jaggi.

According to Dr. Jaggi, quantitative PCR, culture and human adenovirus typing methods may help distinguish human adenovirus disease mimicking Kawasaki disease from Kawasaki disease with accompanying human adenovirus detection.


Story Source:

The above story is based on materials provided by Nationwide Children's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Jaggi, A. E. Kajon, A. Mejias, O. Ramilo, A. Leber. Human Adenovirus Infection in Kawasaki Disease: A Confounding Bystander? Clinical Infectious Diseases, 2012; DOI: 10.1093/cid/cis807

Cite This Page:

Nationwide Children's Hospital. "High fever and evidence of a virus? Caution, it still may be Kawasaki disease." ScienceDaily. ScienceDaily, 5 November 2012. <www.sciencedaily.com/releases/2012/11/121105114501.htm>.
Nationwide Children's Hospital. (2012, November 5). High fever and evidence of a virus? Caution, it still may be Kawasaki disease. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2012/11/121105114501.htm
Nationwide Children's Hospital. "High fever and evidence of a virus? Caution, it still may be Kawasaki disease." ScienceDaily. www.sciencedaily.com/releases/2012/11/121105114501.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins